What do systematic reviews say?

Add‐on lamotrigine vs placebo

It is very uncertain whether add‐on lamotrigine changes treatment withdrawal compared with placebo (very low certainty).

• Lamotrigine add‐on therapy for drug‐resistant generalised tonic‐clonic seizures 2020 · Cochrane Headline outcomes only
  RR 1.2 [0.72, 1.99]
  2 studies · 270 participants
  Very low

Lamotrigine vs lithium

Lamotrigine showed no clear difference in withdrawal from treatment due to any reason, 6‐12 months after… compared with lithium (moderate certainty).

• Lamotrigine in the maintenance treatment of bipolar disorder 2021 · Cochrane Headline outcomes only
  RR 0.96 [0.88, 1.05]
  4 studies · 636 participants
  Moderate

Lamotrigine vs placebo

Lamotrigine probably leads to lower withdrawal from treatment due to any reason, 6‐12 months after… compared with placebo (moderate certainty).

• Lamotrigine in the maintenance treatment of bipolar disorder 2021 · Cochrane Headline outcomes only
  RR 0.88 [0.78, 0.99]
  4 studies · 700 participants
  Moderate

Lamotrigine vs lithium

• Lamotrigine in the maintenance treatment of bipolar disorder 2021 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Lamotrigine vs placebo

It is very uncertain whether lamotrigine changes withdrawal from treatment due to any reason, up to 12 weeks after… compared with placebo (very low certainty).

• Lamotrigine in the maintenance treatment of bipolar disorder 2021 · Cochrane Headline outcomes only
  RR 1.1 [0.7, 1.74]
  1 study · 195 participants
  Very low

Lamotrigine vs placebo

Summary of findings: lamotrigine showed no clear difference in treatment withdrawal compared with placebo (moderate certainty).

• Lamotrigine add‐on therapy for drug‐resistant focal epilepsy 2023 · Cochrane Headline outcomes only
  RR 1.11 [0.91, 1.37]
  14 studies · 1806 participants
  Moderate