Findings

What do systematic reviews say?

3 questions · 3 findings · 3 reviews · Hypertension

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 33.3%Moderate 2 · 66.7%High 0 · 0%

First‐line calcium channel blocker vs placebo

Stroke · adults with primary hypertension

First‐line calcium channel blocker may leads to lower total stroke compared with placebo (low certainty).

1 finding from 1 review

First‐line drugs for hypertension 2018 · Cochrane Headline outcomes only
RR 0.58 [0.41, 0.84]
1 study · 4695 participants
Low

Beta‐blockers vs calcium channel blockers

Stroke

Beta‐blockers probably leads to higher total stroke compared with calcium‐channel blockers (moderate certainty).

1 finding from 1 review

Beta‐blockers for hypertension 2017 · Cochrane Headline outcomes only
RR 1.24 [1.11, 1.4]
3 studies · 44167 participants
Moderate

First‐line thiazides vs calcium channel blockers

Stroke · patients with hypertension

First‐line thiazides showed no clear difference in total stroke Duration: 1 to 5 years compared with first‐line calcium channel blockers (moderate certainty).

1 finding from 1 review

First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
RR 1.06 [0.95, 1.18]
6 studies · 35217 participants
Moderate