What do systematic reviews say?

Oral + inhaled dual therapy vs oral monotherapy

It is very uncertain whether oral + inhaled dual therapy changes serious adverse events. Outcome assessed on day 42 compared with oral monotherapy (very low certainty).

• Dual antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
  OR 0.48 [0.08, 2.87]
  1 study · 53 participants
  Very low

Children: higher dose/longer course vs lower dose/shorter course

• Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 201 participants
  GRADE not reported

Children: prednisolone vs dexamethasone

• Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 255 participants
  GRADE not reported

Macrolide+tetracycline vs macrolides

It is very uncertain whether macrolide+tetracycline changes all‐cause serious adverse events 60 weeks (end of study) compared with macrolide (very low certainty).

• Head‐to‐head oral prophylactic antibiotic therapy for chronic obstructive pulmonary disease 2019 · Cochrane Headline outcomes only
  OR 1 [0.52, 1.93]
  1 study · 198 participants
  Very low

Quinolone vs macrolides

The review found no eligible studies for this question.

• Head‐to‐head oral prophylactic antibiotic therapy for chronic obstructive pulmonary disease 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Macrolides vs tetracycline

The review found no eligible studies for this question.

• Head‐to‐head oral prophylactic antibiotic therapy for chronic obstructive pulmonary disease 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Quinolone vs tetracycline

The review found no eligible studies for this question.

• Head‐to‐head oral prophylactic antibiotic therapy for chronic obstructive pulmonary disease 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found