Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

39 questions · 39 findings · 21 reviews

No studies found 4 · 10.3%GRADE not reported 1 · 2.6%Very low 11 · 28.2%Low 15 · 38.5%Moderate 5 · 12.8%High 3 · 7.7%

High‐dose corticosteroids vs moderate‐dose or no corticosteroids

Serious adverse events · adults with metastatic extradural spinal cord compression (without peptic ulceration or infection; mixed prognosis)

High‐dose corticosteroids probably leads to higher serious adverse events compared with moderate‐dose or no corticosteroids (moderate certainty).

1 finding from 1 review