Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

54 questions · 54 findings · 21 reviews · Headline outcomes only

No studies found 11 · 20.4%GRADE not reported 2 · 3.7%Very low 16 · 29.6%Low 18 · 33.3%Moderate 7 · 13%High 0 · 0%

Azathioprine or 6‐mercaptopurine vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Serious adverse events · people with surgically‐induced remission in Crohn's disease

It is very uncertain whether azathioprine or 6‐mercaptopurine changes serious adverse events compared with 5‐aminosalicylic acid (very low certainty).

1 finding from 1 review

Azathioprine or 6‐mercaptopurine vs anti TNF‐ɑ

Serious adverse events · people with surgically‐induced remission in Crohn's disease

It is very uncertain whether azathioprine or 6‐mercaptopurine changes serious adverse events compared with anti TNF‐α (very low certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events · Patients with active Crohn's disease

The intervention showed no clear difference in serious adverse events (low certainty).

1 finding from 1 review