Findings

What do systematic reviews say?

4 questions · 6 findings · 2 reviews · Tobacco Addiction

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 3 · 50%Low 3 · 50%Moderate 0 · 0%High 0 · 0%

Varenicline vs combination nicotine replacement therapy

SAEs · people who smoke

Varenicline showed no clear difference in SAEs compared with combination nicotine replacement therapy (low certainty).

1 finding from 1 review

Nicotine receptor partial agonists for smoking cessation 2023 · Cochrane Headline outcomes only
RR 2.15 [0.49, 9.46]
4 studies · 1852 participants
Low

Longer vs shorter duration of combination nicotine replacement therapy

SAEs · people who smoke

It is very uncertain whether longer changes overall SAEs ‐ 26 weeks versus 8 weeks compared with shorter duration of combination nicotine replacement therapy (very low certainty).

3 findings from 1 review

Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation 2023 · Cochrane Headline outcomes only
RR 1.63 [0.6, 4.42]
1 study · 544 participants
Very low
Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 637 participants
Very low
Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 987 participants
Very low

Varenicline vs combination nicotine replacement therapy

Cardiac SAEs · people who smoke

Varenicline showed no clear difference in cardiac SAEs compared with combination nicotine replacement therapy (low certainty).

1 finding from 1 review

Nicotine receptor partial agonists for smoking cessation 2023 · Cochrane Headline outcomes only
RR 0.32 [0.01, 7.88]
2 studies · 819 participants
Low

Varenicline vs combination nicotine replacement therapy

Neuropsychiatric SAEs · people who smoke

Varenicline showed no clear difference in neuropsychiatric SAEs compared with combination nicotine replacement therapy (low certainty).

1 finding from 1 review

Nicotine receptor partial agonists for smoking cessation 2023 · Cochrane Headline outcomes only
RR 4.69 [0.23, 96.5]
2 studies · 764 participants
Low