Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

15 questions · 16 findings · 3 reviews · ENT

No studies found 9 · 56.3%GRADE not reported 0 · 0%Very low 5 · 31.3%Low 2 · 12.5%Moderate 0 · 0%High 0 · 0%

Antibiotics vs no treatment or placebo on top of topical antibiotics

Resolution of ear discharge ‐ measured after 4 weeks · people with CSOM; one study included patients of unknown age; one study included children with CSOM who had not responded to initial…

It is very uncertain whether systemic antibiotics changes resolution of ear discharge ‐ measured after 4 weeks (4 weeks)… compared with no treatment or placebo on top of topical antibiotics (very low certainty).

2 findings from 1 review

Antibiotics vs no treatment or placebo on top of topical antibiotics

Resolution of ear discharge ‐ measured at 1 to 2 weeks · people (of any age) with CSOM

Systemic antibiotics showed no clear difference in resolution of ear discharge ‐ measured at 1 to 2 weeks compared with no treatment or placebo on top of topical antibiotics (low certainty).

1 finding from 1 review

Antibiotics vs no treatment or placebo on top of topical antiseptics

Resolution of ear discharge ‐ measured after 4 weeks · schoolchildren with CSOM

It is very uncertain whether systemic antibiotics changes resolution of ear discharge (4 weeks or more) ‐ measured at 3 to 4… compared with no treatment or placebo on top of topical antiseptics (very low certainty).

1 finding from 1 review

Quinolone vs aminoglycosides

Resolution of ear discharge ‐ measured at 1 to 2 weeks · people (of any age) with CSOM

It is very uncertain whether quinolones changes resolution of ear discharge ‐ measured at 1 to 2 weeks compared with aminoglycosides (very low certainty).

1 finding from 1 review

Intervention not reported

Resolution of ear discharge‐ measured at 1 to 2 weeks · CSOM, recurrence of CSOM or suppuration following mastoidectomy or tympanoplasty

The intervention may leads to higher resolution of ear discharge‐ measured at 1 to 2 weeks (low certainty).

1 finding from 1 review

Intervention not reported

Resolution of ear discharge ‐ measured after 4 weeks · CSOM, recurrence of CSOM or suppuration following mastoidectomy or tympanoplasty

The review found no eligible studies for this question.

1 finding from 1 review