Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 6 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

6% sodium fluoride with 6% calcium fluoride varnish vs no treatment

Remineralisation of early enamel caries · Children with early enamel caries (permanent dentition)

One trial found 6% sodium fluoride plus 6% calcium fluoride varnish significantly reversed early enamel caries versus no treatment; ungraded and not meta-analysed.

1 finding from 1 review

Caries remineralisation and arresting effect in children by professionally applied fluoride treatment - a systematic… 2016 All outcomes
Children in clinical dental settings
One study (Xhemnica 2008) reported a significant reversal of early enamel caries using 6% NaF with 6% calcium fluoride compared with no treatment; this study was excluded from the meta-analysis.
1 study
GRADE not reported

1.23% APF gel vs Not specified

Remineralisation of early enamel caries · Children with early (incipient) enamel caries

One trial found acidulated phosphate fluoride gel did not remineralise early enamel caries; ungraded.

1 finding from 1 review

Caries remineralisation and arresting effect in children by professionally applied fluoride treatment - a systematic… 2016 All outcomes
Children in clinical dental settings
One double-blind randomised trial found acidulated phosphate fluoride gel was not effective to remineralise early enamel caries.
1 study
GRADE not reported

Fluoride gel (topically applied; operator- or self-applied; any fluoride agent/concentration; frequency at least once a year) vs Not specified

Remineralisation of early enamel caries · Children with early (incipient) enamel caries

One trial found sodium fluoride gel significantly remineralised early enamel caries; ungraded.

1 finding from 1 review

Caries remineralisation and arresting effect in children by professionally applied fluoride treatment - a systematic… 2016 All outcomes
Children in clinical dental settings
One study using sodium fluoride gel showed a significant remineralising effect on early enamel caries.
1 study
GRADE not reported

10% silver diamine fluoride (SDF) vs Glass ionomer restoration and tooth-brushing

Remineralisation of early enamel caries · Children with early enamel caries in erupting permanent first molars

One pilot study found 10% silver diamine fluoride worked about as well as glass ionomer restoration and tooth-brushing for remineralising early enamel caries; ungraded.

1 finding from 1 review

Caries remineralisation and arresting effect in children by professionally applied fluoride treatment - a systematic… 2016 All outcomes
Children in clinical dental settings
A pilot study found 10% silver diamine fluoride therapy, glass ionomer restoration, and tooth-brushing had a similar effect in remineralising early enamel caries.
1 study
GRADE not reported

Fluoride varnish vs Untreated lesions (single-arm before vs after proportion)

Remineralisation of early enamel caries · Patients (mainly children) with white spot lesions (WSL)

Professionally applied 5% sodium fluoride varnish remineralised about two-thirds of early enamel caries lesions in children (pooled proportion 63.6%, 95% CI 36.0% to 91.2%; 4 studies); certainty was not GRADE-rated and heterogeneity was very high (I2=96%).

1 finding from 1 review

Caries remineralisation and arresting effect in children by professionally applied fluoride treatment - a systematic… 2016 All outcomes
Children in clinical dental settings
Proportion 0.636 [0.360, 0.912]
4 studies
GRADE not reported

Intervention not reported

Remineralisation of early enamel caries

1 finding from 1 review

Caries remineralisation and arresting effect in children by professionally applied fluoride treatment - a systematic… 2016 All outcomes
NaF varnish plus chlorhexidine or calcium fluoride vs NaF varnish alone (no significant added benefit)
no estimate extracted
3 studies
GRADE not reported