What do systematic reviews say?

5 questions · 5 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 4 · 80%Very low 0 · 0%Low 0 · 0%Moderate 1 · 20%High 0 · 0%

Fluoride-releasing resin-based sealant vs Non-invasive measures (fluoride varnish; no intervention)

Radiographic proximal caries lesion progression · Children and adults with non-cavitated proximal (interproximal) caries lesions in primary and/or permanent teeth (ages 3-45)

Pooling 2 trials, resin-based sealants reduced radiographic proximal caries progression versus non-invasive measures (OR 0.24; ungraded subgroup).

1 finding from 1 review

Microinvasive interventions in the management of proximal caries lesions in primary and permanent teeth- systematic… 2025 All outcomes
Final follow-up (1 to 3.5 years) · Multiple countries (Brazil, Saudi Arabia, Netherlands, USA, Turkey, Switzerland, Germany, New Zealand, Chile, Thailand); dental clinic/community settings · Sealant vs non-invasive (Fig. 5, subgroup 2.1.2)
OR 0.24 [0.10, 0.55]
2 studies · 111 participants
GRADE not reported

Microinvasive techniques (resin infiltration or glass ionomer varnish) vs Non-invasive measures (fluoride varnish/toothpaste, flossing, oral hygiene instruction, sham/standard of care)

Radiographic proximal caries lesion progression · Children with non-cavitated proximal caries lesions in primary teeth (ages 3-9)

In primary teeth (5 trials), microinvasive techniques reduced radiographic proximal caries progression versus non-invasive measures (OR 0.38; ungraded subgroup).

1 finding from 1 review

Microinvasive interventions in the management of proximal caries lesions in primary and permanent teeth- systematic… 2025 All outcomes
Final follow-up (1 to 2 years across trials) · Multiple countries (Brazil, Saudi Arabia, Netherlands, USA, Turkey, Switzerland, Germany, New Zealand, Chile, Thailand); dental clinic/community settings · Primary teeth (Fig. 6, subgroup 2.1.2)
OR 0.38 [0.25, 0.57]
5 studies · 266 participants
GRADE not reported

Microinvasive techniques (resin infiltration, resin/GIC sealant, or glass ionomer varnish) vs Non-invasive measures (fluoride varnish/toothpaste, flossing, oral hygiene instruction, sham/standard of care)

Radiographic proximal caries lesion progression · Children and adults with non-cavitated proximal (interproximal) caries lesions in primary and/or permanent teeth (ages 3-45)

Microinvasive techniques probably reduce radiographic progression of non-cavitated proximal caries lesions compared with non-invasive measures (moderate certainty).

1 finding from 1 review

Microinvasive interventions in the management of proximal caries lesions in primary and permanent teeth- systematic… 2025 All outcomes
Final follow-up (1 to 7 years across trials) · Multiple countries (Brazil, Saudi Arabia, Netherlands, USA, Turkey, Switzerland, Germany, New Zealand, Chile, Thailand); dental clinic/community settings · Overall (all microinvasive vs non-invasive pooled)
OR 0.27 [0.19, 0.38]
13 studies · 623 participants
Moderate

Resin infiltration vs Non-invasive measures (fluoride varnish/toothpaste, flossing, oral hygiene instruction, sham/standard of care)

Radiographic proximal caries lesion progression · Children and adults with non-cavitated proximal (interproximal) caries lesions in primary and/or permanent teeth (ages 3-45)

Pooling 10 trials, resin infiltration reduced radiographic proximal caries progression versus non-invasive measures (OR 0.23); this subgroup was not separately GRADE-rated.

1 finding from 1 review

Microinvasive interventions in the management of proximal caries lesions in primary and permanent teeth- systematic… 2025 All outcomes
Final follow-up (1 to 7 years across trials) · Multiple countries (Brazil, Saudi Arabia, Netherlands, USA, Turkey, Switzerland, Germany, New Zealand, Chile, Thailand); dental clinic/community settings · Resin infiltration vs non-invasive (Fig. 5, subgroup 2.1.1)
OR 0.23 [0.15, 0.35]
10 studies · 459 participants
GRADE not reported

Microinvasive techniques (mostly resin infiltration; incl. resin sealant) vs Non-invasive measures (fluoride varnish/toothpaste, flossing, oral hygiene instruction, sham/standard of care)

Radiographic proximal caries lesion progression · Children and adults with non-cavitated proximal caries lesions in permanent teeth (ages 11-45)

In permanent teeth (7 trials), microinvasive techniques reduced radiographic proximal caries progression versus non-invasive measures (OR 0.18; ungraded subgroup).

1 finding from 1 review

Microinvasive interventions in the management of proximal caries lesions in primary and permanent teeth- systematic… 2025 All outcomes
Final follow-up (1 to 7 years across trials) · Multiple countries (Brazil, Saudi Arabia, Netherlands, USA, Turkey, Switzerland, Germany, New Zealand, Chile, Thailand); dental clinic/community settings · Permanent teeth (Fig. 6, subgroup 2.1.1)
OR 0.18 [0.10, 0.32]
7 studies · 296 participants
GRADE not reported