Findings

What do systematic reviews say?

21 questions · 21 findings · 9 reviews · Headline outcomes only

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No studies found 7 · 33.3%GRADE not reported 4 · 19%Very low 5 · 23.8%Low 3 · 14.3%Moderate 2 · 9.5%High 0 · 0%

Antidepressants vs placebo

Quality of life · people with inflammatory bowel disease

1 finding from 1 review

Adjuvant therapy with antidepressants for the management of inflammatory bowel disease 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 70 participants
Low

Antidepressants vs a combination of medications

Quality of life at post‐treatment Indexed by self‐report measures of quality of life or functional disability · somatoform disorders in adults

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for somatoform disorders in adults 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Exercise therapy plus antidepressants vs antidepressants alone

QoL · men and women aged over 18 years with chronic fatigue syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Exercise therapy for chronic fatigue syndrome 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Tricyclic antidepressants vs another medication

Quality of life at post‐treatment Indexed by self‐report measures of quality of life or functional disability · somatoform disorders in adults

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for somatoform disorders in adults 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Tricyclic antidepressants vs placebo

Functional disability and quality of life (post‐treatment score on self report and clinician‐rated scales) · somatoform disorders in adults

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for somatoform disorders in adults 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

New‐generation antidepressants vs placebo

Quality of life at post‐treatment Indexed by self‐report measures of quality of life or functional disability · somatoform disorders in adults

1 finding from 1 review

Pharmacological interventions for somatoform disorders in adults 2014 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 163 participants
Very low

Discontinuation with high‐intensity psychological interventions vs continuation

Quality of life · participants with long‐term antidepressants for depressive disorders

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 455 participants
Very low

Discontinuation of long‐term antidepressant with minimal intervention vs usual care

Quality of life · participants with long‐term antidepressants for depressive or anxiety disorders

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 146 participants
Very low

Abrupt discontinuation vs continuation of long‐term antidepressants

Quality of life · participants with depressive or anxiety disorders

The review found no eligible studies for this question.

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

SSRIs or SNRIs vs other antidepressants

Quality of life · patients with tension‐type headache

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Fluoxetine vs placebo

Quality of life · adults with seasonal affective disorder

The review found no eligible studies for this question.

1 finding from 1 review

Second‐generation antidepressants for treatment of seasonal affective disorder 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Amitriptyline vs nomifensine

Quality of life · people with epilepsy and depression

1 finding from 1 review

Antidepressants for people with epilepsy and depression 2021 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Venlafaxine vs no treatment

Quality of life · people with epilepsy and depression

1 finding from 1 review

Antidepressants for people with epilepsy and depression 2021 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Intervention not reported

Quality of life · people with epilepsy and depression

1 finding from 1 review

Antidepressants for people with epilepsy and depression 2021 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Paroxetine vs doxepin

Quality of life · people with epilepsy and depression

1 finding from 1 review

Antidepressants for people with epilepsy and depression 2021 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Exercise therapy vs antidepressants

QoL · men and women aged over 18 years with chronic fatigue syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Exercise therapy for chronic fatigue syndrome 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Selective serotonin reuptake inhibitors vs cognitive behavioural therapy

Post‐treatment quality of life (QOLIE‐31 score, which has a range of 0‐200, with higher score indicates better quality of life) ( · people with epilepsy and depression

1 finding from 1 review

Antidepressants for people with epilepsy and depression 2021 · Cochrane Headline outcomes only
no estimate extracted
15 participants
Very low

Antidepressants vs placebo

Quality of life score at 8 weeks · adults living with HIV and depression

1 finding from 1 review

Antidepressants for depression in adults with HIV infection 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 87 participants
Very low

Fluoxetine vs light therapy

Quality of life (SF‐20 & Q‐LES‐Q) Eight weeks · adults with seasonal affective disorder

1 finding from 1 review

Second‐generation antidepressants for treatment of seasonal affective disorder 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 96 participants
Low

Sertraline vs cognitive behavioural therapy

Quality of life (QOLIE‐89) (1‐ to 3‐month periods) · people with epilepsy and depression

1 finding from 1 review

Antidepressants for people with epilepsy and depression 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 118 participants
Moderate