What do systematic reviews say?

Summary of findings ‐ Inhaled mannitol vs placebo

Inhaled mannitol showed no clear difference in health‐related quality of life measured on the SGRQ Scale from 0 to… compared with placebo (moderate certainty).

• Inhaled hyperosmolar agents for bronchiectasis 2014 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 840 participants
  Moderate

Intervention not reported

It is very uncertain whether the intervention changes subjective Health Status score (Assessment of Quality of Life Score… (very low certainty).

• Very early versus delayed mobilisation after stroke 2018 · Cochrane Headline outcomes only
  MD 0.07
  1 study · 68 participants
  Very low

Autoinflation vs no treatment

• Autoinflation for otitis media with effusion (OME) in children 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Low

Mepolizumab 100 mg vs placebo

• Anti‐IL‐5 therapies for chronic obstructive pulmonary disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 1285 participants
  Moderate

Dietary interventions vs usual care

• Lifestyle changes for treating psoriasis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 36 participants
  Moderate

Reablement vs usual home‐care

• Time‐limited home‐care reablement services for maintaining and improving the functional independence of older adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 249 participants
  Very low

Benralizumab 10 mg vs placebo

• Anti‐IL‐5 therapies for chronic obstructive pulmonary disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 680 participants
  Moderate

Benralizumab 30 mg vs placebo

• Anti‐IL‐5 therapies for chronic obstructive pulmonary disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 1333 participants
  Moderate

Benralizumab 100 mg vs placebo

• Anti‐IL‐5 therapies for chronic obstructive pulmonary disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 1351 participants
  High

Mepolizumab 300 mg vs placebo

• Anti‐IL‐5 therapies for chronic obstructive pulmonary disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 451 participants
  Moderate

Mepolizumab 100 mg vs placebo

• Anti‐IL‐5 therapies for chronic obstructive pulmonary disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 911 participants
  Moderate

Mucolytic vs placebo

• Mucolytic agents versus placebo for chronic bronchitis or chronic obstructive pulmonary disease 2019 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 2721 participants
  Moderate

Combination of manual therapy, exercise, electrotherapy and placebo injection vs glucocorticoid injection

• Manual therapy and exercise for adhesive capsulitis (frozen shoulder) 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 49 participants
  Low

Combination of manual therapy, exercise, electrotherapy and placebo injection vs placebo injection

• Manual therapy and exercise for adhesive capsulitis (frozen shoulder) 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 49 participants
  Low

Combination of manual therapy, exercise, electrotherapy and glucocorticoid injection vs glucocorticoid injection

• Manual therapy and exercise for adhesive capsulitis (frozen shoulder) 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 44 participants
  Low

Cognitive‐behavioural intervention vs controls

• Cognitive behavioural therapies for fibromyalgia 2013 · Cochrane Headline outcomes only
  no estimate extracted
  13 studies · 1238 participants
  Low

Intervention not reported

• Exercise for improving outcomes after osteoporotic vertebral fracture 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 109 participants
  Very low

Serotonin and noradrenaline reuptake inhibitors (SNRI) vs placebo

Serotonin noradrenaline reuptake inhibitors showed no clear difference in self‐reported health‐related quality of life (0‐100 scale) Higher… compared with placebo (low certainty).

• Serotonin and noradrenaline reuptake inhibitors (SNRIs) for fibromyalgia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  14 studies · 6861 participants
  Low

Urodynamics vs clinical management (CM)

• Urodynamic studies for management of urinary incontinence in children and adults 2013 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 75 participants
  Moderate

Information or education intervention vs no education

• Information or education interventions for adult intensive care unit (ICU) patients and their carers 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 143 participants
  Very low