What do systematic reviews say?

Pilocarpine vs no treatment/placebo

It is very uncertain whether pilocarpine changes quality of life (McMaster HNRQ, 1-7 scale) compared with no treatment/placebo (very low certainty).

• Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes

  Up to and including 6 months postRT
  MD 0.20 [-0.19, 0.59]
  1 study · 90 participants
  Very low

Selective serotonin reuptake inhibitors vs placebo

• Pharmacological interventions for the treatment of depression in chronic obstructive pulmonary disease 2018 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 148 participants
  Very low

Tricylic antidepressant vs placebo

• Pharmacological interventions for the treatment of depression in chronic obstructive pulmonary disease 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 30 participants
  Very low

Surgery vs Pharmacological therapy

Surgery alone showed no clear difference in health‐related quality of life Mean AcroQoL score (0‐100) compared with pharmacological therapy alone (low certainty).

• Surgical and non‐surgical interventions for primary and salvage treatment of growth hormone‐secreting pituitary… 2024 · Cochrane Headline outcomes only
  MD 10
  1 study · 22 participants
  Low

Amifostine vs no treatment/placebo

It is very uncertain whether amifostine changes quality of life (Patient Benefit Questionnaire, 10-point scale) compared with no treatment/placebo (very low certainty).

• Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes

  12 months postRT
  MD 0.70 [0.20, 1.20]
  1 study · 180 participants
  Very low

Glycerol laxative vs acupuncture

The review found no eligible studies for this question.

• Pharmacological treatment for antipsychotic‐related constipation 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Mannitol vs phenolphthalein or rhubarb soda

The review found no eligible studies for this question.

• Pharmacological treatment for antipsychotic‐related constipation 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Glycerol laxative vs tuina massage

The review found no eligible studies for this question.

• Pharmacological treatment for antipsychotic‐related constipation 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Antihypertensive drug therapy vs placebo

• Pharmacological treatment of hypertension in people without prior cerebrovascular disease for the prevention of… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 15795 participants
  Very low

Diflunisal vs placebo

• Pharmacological treatment for familial amyloid polyneuropathy 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 130 participants
  Very low

Diflunisal vs placebo

• Pharmacological treatment for familial amyloid polyneuropathy 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 130 participants
  Very low

Patisiran vs placebo

• Pharmacological treatment for familial amyloid polyneuropathy 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 225 participants
  Low

Inotersen vs placebo

• Pharmacological treatment for familial amyloid polyneuropathy 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 172 participants
  Low

Tafamidis vs placebo

• Pharmacological treatment for familial amyloid polyneuropathy 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 125 participants
  Very low