Findings

What do systematic reviews say?

102 questions · 102 findings · 46 reviews

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No studies found 56 · 54.9%GRADE not reported 10 · 9.8%Very low 14 · 13.7%Low 15 · 14.7%Moderate 4 · 3.9%High 3 · 2.9%

Intervention not reported

Quality of life · patients with extensive SCLC who relapsed or progressed after first‐line chemotherapy

The intervention may leads to higher quality of life (low certainty).

1 finding from 1 review

Chemotherapy versus best supportive care for extensive small cell lung cancer 2013 · Cochrane Headline outcomes only
RR 2.18 [0.05, 0.25]
1 study · 141 participants
Low

Intervention not reported

Quality of life ‐ not reported · Adults with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem…

The review found no eligible studies for this question.

1 finding from 1 review

Restrictive versus liberal red blood cell transfusion strategies for people with haematological malignancies treated… 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings 2: PLD alone vs other conventional chemotherapy

Quality of life · recurrent platinum‐resistant EOC

The review found no eligible studies for this question.

1 finding from 1 review

Pegylated liposomal doxorubicin for relapsed epithelial ovarian cancer 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Capecitabine‐containing regimens vs chemotherapy regimens without capecitabine

Quality of life · people with metastatic breast cancer

1 finding from 1 review

Capecitabine for hormone receptor‐positive versus hormone receptor‐negative breast cancer 2021 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 5 participants
Low

EGFR tyrosine kinase inhibitor (TKI) vs observation

Quality of life · maintenance treatment of epithelial ovarian cancer after first‐line chemotherapy

1 finding from 1 review

Epidermal growth factor receptor blockers for the treatment of ovarian cancer 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 835 participants
Very low

Probiotics vs placebo

Quality of life ‐ not measured · participants with cancer treated with chemotherapy

The review found no eligible studies for this question.

1 finding from 1 review

Probiotics for the prevention or treatment of chemotherapy‐ or radiotherapy‐related diarrhoea in people with cancer 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Probiotics vs other active intervention

Quality of life ‐ not measured · participants with cancer treated with radiotherapy (with or without chemotherapy)

The review found no eligible studies for this question.

1 finding from 1 review

Probiotics for the prevention or treatment of chemotherapy‐ or radiotherapy‐related diarrhoea in people with cancer 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Probiotics vs placebo

Quality of life ‐ not measured · participants with cancer treated with radiotherapy (with or without chemotherapy)

The review found no eligible studies for this question.

1 finding from 1 review

Probiotics for the prevention or treatment of chemotherapy‐ or radiotherapy‐related diarrhoea in people with cancer 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Amifostine vs no treatment/placebo

Quality of life · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region

Amifostine showed no clear difference in quality of life compared with no treatment/placebo; GRADE not reported.

1 finding from 1 review

Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes
End of RT; up to 3 months postRT
MD 0.52 [-0.02, 1.06]
1 study · 233 participants
GRADE not reported

Antiseptic mouthrinse vs placebo

Quality of life · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes
No quality of life data were reported.
0 studies
No studies found

Bethanechol vs placebo

Quality of life · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes
No data on either quality of life or other oral related symptoms were reported.
0 studies
No studies found

Chinese medicine vs no treatment/placebo

Quality of life · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region

1 finding from 1 review

Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes
End of intervention to 3 months postRT
Insufficient evidence to determine any effect on quality of life (Lin 2014; Analysis 6.5)
1 study
GRADE not reported

Amifostine (intravenous) vs Amifostine (subcutaneous)

Quality of life · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes
No data on either quality of life or other oral related symptoms were reported.
0 studies
No studies found

Venalot Depot (coumarin plus troxerutin) vs placebo

Quality of life · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes
No data on either quality of life or other oral related symptoms were reported.
0 studies
No studies found

Amifostine 200 mg/m2 three times weekly vs Amifostine 200 mg/m2 five times weekly

Quality of life · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region

1 finding from 1 review

Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes
End of RT and 6, 12, 18, 24 months postRT
No significant differences between the three treatment arms (Jellema 2006)
1 study
GRADE not reported

Bethanechol vs Artificial saliva

Quality of life · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes
No data on either quality of life or other oral related symptoms were reported.
0 studies
No studies found

Intervention not reported

Quality of life ‐ not reported · people with haematological disorders undergoing intensive chemotherapy or stem cell transplantation

The review found no eligible studies for this question.

1 finding from 1 review

Alternatives, and adjuncts, to prophylactic platelet transfusion for people with haematological malignancies… 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Thrombopoietin mimetics vs placebo or usual care

Quality of life ‐ not reported · people with haematological disorders undergoing intensive chemotherapy or stem cell transplantation

The review found no eligible studies for this question.

1 finding from 1 review

Alternatives, and adjuncts, to prophylactic platelet transfusion for people with haematological malignancies… 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Therapeutic or non‐prophylactic platelet transfusion vs prophylactic platelet transfusion

Quality of life ‐ not reported · patients with haematological disorders undergoing myelosuppressive chemotherapy or stem cell transplantation

1 finding from 1 review

A therapeutic‐only versus prophylactic platelet transfusion strategy for preventing bleeding in patients with… 2015 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Phenytoin mouthrinse vs placebo

Quality of life · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

Phenytoin mouthrinse led to lower quality of life compared with placebo; GRADE not reported.

1 finding from 1 review

Interventions for treating oral mucositis for patients with cancer receiving treatment 2010 · Cochrane All outcomes
7 days
MD -15.10 [-26.04, -4.16]
1 study · 12 participants
GRADE not reported