What do systematic reviews say?

Augmentation of current antidepressant (SSRI/SNRI) with mirtazapine (30 mg/d) vs augmentation of current antidepressant (various) with placebo

• Pharmacological interventions for treatment‐resistant depression in adults 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 447 participants
  High

Exposure to pulsed magnetic fields (in addition to self‐care and protective footwear) vs self‐care and footwear

The review found no eligible studies for this question.

• Interventions for ulceration and other skin changes caused by nerve damage in leprosy 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

• Lay‐led and peer support interventions for adolescents with asthma 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 251 participants
  Low

Fluticasone propionate spray vs Betamethasone sodium phosphate mouthwash

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  No statistical testing of the Oral Health Quality of Life index (OHQoL16) was reported in Hegarty 2002 (fluticasone mean score 0.7 versus betamethasone mean score -0.8).
  1 study · 22 participants
  GRADE not reported

Physical activity vs usual care

• Physical activity interventions for disease‐related physical and mental health during and following treatment in… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 230 participants
  Moderate

Smart technology vs face‐to‐face/digital and/or written support

• Computer and mobile technology interventions for self‐management in chronic obstructive pulmonary disease 2017 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 472 participants
  Low

Intervention not reported

• Lay‐led and peer support interventions for adolescents with asthma 2017 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 578 participants
  Low

Interferon vs no intervention

It is very uncertain whether interferon changes health‐related quality of life (1 week) compared with no intervention (very low certainty).

• Pharmacological interventions for acute hepatitis B infection 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 100 participants
  Very low

Lamivudine vs no intervention

The review found no eligible studies for this question.

• Pharmacological interventions for acute hepatitis B infection 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Experimental chewing adjuncts (bite wafers or chewing gum) vs No chewing gum, placebo, or control (no adjunct)

Experimental chewing adjuncts (bite wafers or chewing gum) led to lower quality of life or patient satisfaction compared with no chewing gum, placebo, or control (no adjunct); GRADE not reported.

• Non‐pharmacological interventions for alleviating pain during orthodontic treatment 2016 · Cochrane All outcomes

  24 hours
  RR 0.45 [0.22, 0.94]
  2 studies · 107 participants
  GRADE not reported

Idebenone vs placebo

The review found no eligible studies for this question.

• Interventions for preventing and treating cardiac complications in Duchenne and Becker muscular dystrophy and X‐linked… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Eplerenone (25 mg daily) vs placebo

The review found no eligible studies for this question.

• Interventions for preventing and treating cardiac complications in Duchenne and Becker muscular dystrophy and X‐linked… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Prophylactic perindopril (2 mg to 4 mg daily) vs placebo

The review found no eligible studies for this question.

• Interventions for preventing and treating cardiac complications in Duchenne and Becker muscular dystrophy and X‐linked… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Lisinopril (0.7 mg/kg daily) vs losartan (0.7 mg/kg daily)

The review found no eligible studies for this question.

• Interventions for preventing and treating cardiac complications in Duchenne and Becker muscular dystrophy and X‐linked… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Finasteride vs placebo

• Interventions for female pattern hair loss 2016 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Low‐level laser comb vs Placebo (sham/placebo device)

• Interventions for female pattern hair loss 2016 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Electrical or magnetic stimulation vs no treatment, sham treatment or verbal/written instruction

The review found no eligible studies for this question.

• Conservative interventions for managing urinary incontinence after prostate surgery 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Combinations of conservative treatments vs no treatment, sham treatment or verbal/written instruction

Combinations of conservative treatments showed no clear difference in general quality of life: > 6 to 12 months compared with no treatment, sham treatment or verbal/written instruction (moderate certainty).

• Conservative interventions for managing urinary incontinence after prostate surgery 2023 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 742 participants
  Moderate

Pelvic floor muscle training (PFMT) plus biofeedback vs no treatment, sham treatment or verbal/written instruction

The review found no eligible studies for this question.

• Conservative interventions for managing urinary incontinence after prostate surgery 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Escitalopram vs placebo

The review found no eligible studies for this question.

• Early pharmacological interventions for prevention of post‐traumatic stress disorder (PTSD) in individuals… 2024 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found