Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3 questions · 3 findings · 1 reviews · Musculoskeletal

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 33.3%Moderate 1 · 33.3%High 1 · 33.3%

Anti‐TNF discontinuation vs anti‐TNF continuation

Proportion of participants with minimal radiographic progression · people with rheumatoid arthritis with low disease activity using a standard dose of anti‐TNF agents

Anti‐TNF discontinuation leads to higher proportion participants with minimal radiographic progression compared with anti‐TNF continuation (high certainty).

1 finding from 1 review

Anti‐TNF disease activity–guided dose tapering vs anti‐TNF continuation

Proportion of participants with minimal radiographic progression · people with rheumatoid arthritis with low disease activity using a standard dose of anti‐TNF agents

Anti‐TNF disease activity–guided dose tapering showed no clear difference in proportion of participants with minimal radiographic progression compared with anti‐TNF continuation (low certainty).

1 finding from 1 review

Anti‐TNF dose reduction vs anti‐TNF continuation

Proportion of participants with minimal radiographic progression · people with rheumatoid arthritis with low disease activity using a standard dose of anti‐TNF agents

Anti‐TNF dose reduction showed no clear difference in proportion of participants with minimal radiographic progression compared with anti‐TNF continuation (moderate certainty).

1 finding from 1 review