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What do systematic reviews say?

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Evidence found and GRADE certainty

6 questions · 6 findings · 3 reviews · Headline outcomes only

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No studies found 1 · 16.7%GRADE not reported 0 · 0%Very low 5 · 83.3%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Radix Sophorae flavescentis vs placebo or no intervention

Non‐serious adverse events Maximum · chronic hepatitis B

It is very uncertain whether radix Sophorae flavescentis changes proportion of participants with 1 or more adverse events considered… compared with no intervention or placebo (very low certainty).

1 finding from 1 review

Acupuncture vs no intervention

Proportion of participants with 1 or more serious adverse events · chronic hepatitis B

The review found no eligible studies for this question.

1 finding from 1 review

Methylphenidate vs placebo or no intervention

Proportion of participants with one or more serious adverse events · Children and adolescents with ADHD

It is very uncertain whether methylphenidate changes proportion of participants with one or more serious adverse events compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Methylphenidate vs placebo or no intervention

Adverse events considered non‐serious (penicillin versus doxycycline) · Children and adolescents with ADHD

It is very uncertain whether methylphenidate changes proportion of participants with one or more adverse events… compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Acupuncture vs no intervention

Non‐serious adverse events Maximum · chronic hepatitis B

It is very uncertain whether acupuncture changes proportion of participants with 1 or more adverse events considered… compared with no intervention (very low certainty).

1 finding from 1 review