Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

95 questions · 97 findings · 43 reviews

No studies found 1 · 1%GRADE not reported 30 · 30.9%Very low 15 · 15.5%Low 25 · 25.8%Moderate 15 · 15.5%High 11 · 11.3%

Intramuscular (IM) progesterone vs no treatment or placebo

Preterm birth less than 28 weeks · Women with a multiple pregnancy

Intramuscular (IM) progesterone showed no clear difference in preterm birth less than 28 weeks compared with no treatment or placebo (moderate certainty).

1 finding from 1 review

Dental caries during pregnancy vs Pregnant women without dental caries

Gestational age (preterm birth < 37 weeks) · pregnant women

Pregnant women with dental caries did not have a significantly increased risk of preterm birth (pooled OR 1.16, 95% CI 0.90 to 1.49; 5 studies; I2=35%); certainty of evidence not graded.

1 finding from 1 review
  • Dental caries and preterm birth: a systematic review and meta-analysis. 2018 All outcomes
    Pregnant women assessed around delivery in observational studies across multiple countries (Mexico, Malawi, India, France, Jordan, Finland, Tanzania); mostly retrospective cohort and case-control designs
    OR 1.16 [0.90, 1.49]
    5 studies · 4246 participants
    GRADE not reported

Cervical cerclage in combination with antibiotics and tocolytics vs cervical cerclage

Preterm birth less than 34 weeks' gestation

It is very uncertain whether cervical cerclage in combination with antibiotics and tocolytics changes preterm birth < 34 completed weeks of pregnancy compared with cervical cerclage alone (very low certainty).

1 finding from 1 review

Intervention not reported

Preterm birth < 34 weeks · women carrying twins, asymptomatic for PTL or PPROM

It is very uncertain whether the intervention changes preterm birth < 34 weeks (very low certainty).

1 finding from 1 review

Intervention not reported

Preterm birth < 37 weeks · singleton pregnancy with symptoms of PTL

It is very uncertain whether the intervention changes preterm birth < 37 weeks (very low certainty).

1 finding from 1 review

Periodontal treatment (scaling and root planing, polishing, or surgery), alone or with oral hygiene counselling, antiseptics, or antimicrobials vs no treatment

Preterm birth < 35 weeks · Pregnant women considered to have periodontal disease (gingivitis or periodontitis) after dental examination

It is very uncertain whether periodontal treatment (scaling and root planing, polishing, or… changes preterm birth < 35 weeks compared with no treatment (very low certainty).

1 finding from 1 review

Periodontal treatment (scaling and root planing, polishing, or surgery), alone or with oral hygiene counselling, antiseptics, or antimicrobials vs no treatment

Preterm birth < 32 weeks · Pregnant women considered to have periodontal disease (gingivitis or periodontitis) after dental examination

It is very uncertain whether periodontal treatment (scaling and root planing, polishing, or… changes preterm birth < 32 weeks compared with no treatment (very low certainty).

1 finding from 1 review

Periodontal treatment (scaling and root planing, alone or with antimicrobials) vs Alternative (less intensive) periodontal treatment, alone or with placebo

Preterm birth < 35 weeks · Pregnant women considered to have periodontal disease (gingivitis or periodontitis) after dental examination
1 finding from 1 review

Dental caries during pregnancy vs Pregnant women without dental caries

Preterm birth stratified by gestational age at birth (moderate-to-late 32 to <37, very 28 to <32, extremely <28 weeks) · pregnant women

The planned subanalysis of preterm birth by gestational age at birth (moderate-to-late, very, extremely preterm) could not be performed because of the small number of cases and lack of stratified data in the original studies.

1 finding from 1 review
  • Dental caries and preterm birth: a systematic review and meta-analysis. 2018 All outcomes
    Pregnant women assessed around delivery in observational studies across multiple countries (Mexico, Malawi, India, France, Jordan, Finland, Tanzania); mostly retrospective cohort and case-control designs · By gestational age at birth
    no estimate extracted
    0 studies
    GRADE not reported

Periodontal treatment (scaling and root planing, polishing, or surgery), alone or with oral hygiene counselling, antiseptics, or antimicrobials vs no treatment

Gestational age (preterm birth < 37 weeks) · Pregnant women considered to have periodontal disease (gingivitis or periodontitis) after dental examination

Periodontal treatment (scaling and root planing, polishing, or… showed no clear difference in gestational age (preterm birth < 37 weeks) compared with no treatment (low certainty).

1 finding from 1 review

Periodontal treatment (scaling and root planing, alone or with antimicrobials) vs Alternative (less intensive) periodontal treatment, alone or with placebo

Gestational age (preterm birth < 37 weeks) · Pregnant women considered to have periodontal disease (gingivitis or periodontitis) after dental examination

It is very uncertain whether periodontal treatment (scaling and root planing, alone or with… changes gestational age (preterm birth < 37 weeks) compared with alternative (less intensive) periodontal treatment, alone or with… (very low certainty).

3 findings from 1 review

Community and primary care based maternal oral health interventions vs Usual antenatal care or no structured oral health intervention

Preterm birth (<37 weeks) · Pregnant women and postpartum mothers

Maternal oral health interventions may reduce preterm birth, but the pooled RCT estimate was not statistically significant (low certainty).

1 finding from 1 review

Intervention not reported

Preterm birth < 37 weeks · pregnant women and their babies

The intervention leads to lower preterm birth < 37 weeks (high certainty).

1 finding from 1 review