Findings

What do systematic reviews say?

8 questions · 10 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 5 · 50%Low 3 · 30%Moderate 2 · 20%High 0 · 0%

IUI in a stimulated cycle vs IUI

Pregnancy rate per couple (all cycles) · couples with male subfertility

It is very uncertain whether IUI in stimulated cycles changes pregnancy rate per couple (all cycles) compared with IUI (very low certainty).

1 finding from 1 review

Assisted reproductive technologies for male subfertility 2016 · Cochrane Headline outcomes only
OR 1.68 [1, 2.82]
Studies not reported
Very low

IUI in a stimulated cycle vs IUI

Pregnancy rate per couple (all cycles) · participants with unexplained subfertility

IUI in a stimulated cycle showed no clear difference in pregnancy rate per couple (all cycles) compared with IUI (low certainty).

1 finding from 1 review

Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
OR 6.43 [0.56, 73.35]
1 study · 26 participants
Low

IUI in a natural cycle vs TI

Pregnancy rate per couple (all cycles) · couples with male subfertility

It is very uncertain whether IUI in natural cycles changes pregnancy rate per couple (all cycles) compared with TI (very low certainty).

1 finding from 1 review

Assisted reproductive technologies for male subfertility 2016 · Cochrane Headline outcomes only
OR 4.57 [0.21, 101.61]
Studies not reported
Very low

IUI in a natural cycle vs TI or expectant management

Pregnancy rate per couple (all cycles) · participants with unexplained subfertility

IUI in a natural cycle probably leads to higher pregnancy rate per couple (all cycles) compared with TI or expectant management (moderate certainty).

2 findings from 1 review

Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
OR 1.77 [1.01, 3.08]
1 study · 342 participants
Moderate
Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
OR 1.53 [0.88, 2.64]
1 study · 334 participants
Low

IUI in a stimulated cycle vs TI

Pregnancy rate per couple (all cycles) · couples with male subfertility

It is very uncertain whether IUI in stimulated cycles changes pregnancy rate per couple (all cycles) compared with TI (very low certainty).

2 findings from 1 review

Assisted reproductive technologies for male subfertility 2016 · Cochrane Headline outcomes only
OR 3.14 [0.12, 81.35]
Studies not reported
Very low
Assisted reproductive technologies for male subfertility 2016 · Cochrane Headline outcomes only
OR 1.51 [0.74, 3.07]
Studies not reported
Very low

IUI in a stimulated cycle vs TI or expectant management

Pregnancy rate per couple (all cycles) · participants with unexplained subfertility

IUI in a stimulated cycle may leads to higher pregnancy rate per couple (all cycles) compared with TI or expectant management (low certainty).

1 finding from 1 review

Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
OR 1.69 [1.14, 2.53]
6 studies · 517 participants
Low

IUI in a stimulated cycle vs TI or expectant management

Pregnancy rate · participants with unexplained subfertility

IUI in a stimulated cycle probably leads to higher pregnancy rate per couple (all cycles)‐ clomiphene citrate or… compared with TI or expectant management (moderate certainty).

1 finding from 1 review

Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
OR 4.68 [2.22, 9.86]
1 study · 201 participants
Moderate

IVF vs IUI

Pregnancy rate per couple (all cycles) · couples with male subfertility

It is very uncertain whether IVF changes pregnancy rate per couple (all cycles) compared with IUI (very low certainty).

1 finding from 1 review

Assisted reproductive technologies for male subfertility 2016 · Cochrane Headline outcomes only
OR 1.27 [0.33, 4.97]
Studies not reported
Very low