Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

13 questions · 13 findings · 9 reviews · Headline outcomes only

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 5 · 38.5%Low 2 · 15.4%Moderate 3 · 23.1%High 3 · 23.1%

Neoadjuvant chemotherapy prior to interval surgery (NACT) vs surgery followed by chemotherapy (PDS)

Surgically‐related postoperative mortality (28 days to 6 months of surgery4) · women with advanced ovarian epithelial cancer

Neoadjuvant chemotherapy prior to interval surgery (NACT) leads to lower surgically‐related postoperative mortality (28 days to 6 months of… compared with surgery followed by chemotherapy (PDS) (high certainty).

1 finding from 1 review

Intervention not reported

Postoperative mortality (within 30 days from surgery) · patients with resectable disease

The intervention leads to higher postoperative mortality (within 30 days from surgery) (high certainty).

1 finding from 1 review

Transmyocardial laser revascularization vs medical treatment

Early postoperative mortality Deaths in the 30 days after surgery · patients with refractory angina

Transmyocardial laser revascularization showed no clear difference in early postoperative mortality Deaths in the 30 days after surgery compared with medical treatment (high certainty).

1 finding from 1 review

Preoperative inspiratory muscle training vs usual care, non‐exercise intervention

Mortality In the early postoperative period (≤ 30 days) · adult participants undergoing cardiac and major abdominal surgery

It is very uncertain whether preoperative inspiratory muscle training changes all‐cause mortality within 30 days during postoperative period compared with usual care, non‐exercise intervention (very low certainty).

1 finding from 1 review

Active cerebral oxygenation monitoring vs blinded cerebral oxygenation monitoring

Intraoperative mortality or postoperative mortality: Death ( · children and adults undergoing surgery

Active cerebral oxygenation monitoring showed no clear difference in intraoperative mortality or postoperative mortality: Death ( compared with blinded cerebral oxygenation monitoring (low certainty).

1 finding from 1 review

Laparoscopic vs open surgery

Late overall mortality (after the first 30 postoperative days) · patients with sigmoid diverticulitis

It is very uncertain whether laparoscopic changes late overall mortality (after the first 30 postoperative days) compared with open surgery (very low certainty).

1 finding from 1 review