Findings

What do systematic reviews say?

6 questions · 6 findings · 4 reviews · Neonatal

Sort:Best matchNewest Highest certainty Download CSV

No studies found 2 · 33.3%GRADE not reported 0 · 0%Very low 3 · 50%Low 0 · 0%Moderate 1 · 16.7%High 0 · 0%

Pentoxifylline with antibiotics (any dose or duration) vs pentoxifylline with antibiotics and immunoglobulin M‐enriched intravenous immunoglobulin

Periventricular leukomalacia · neonates with sepsis

The review found no eligible studies for this question.

1 finding from 1 review

Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Pentoxifylline with antibiotics (any dose or duration) vs immunoglobulin M‐enriched intravenous immunoglobulin with antibiotics

Periventricular leukomalacia · neonates with sepsis

The review found no eligible studies for this question.

1 finding from 1 review

Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Pentoxifylline with antibiotics (any dose or duration) vs placebo or no intervention

Periventricular leukomalacia · neonates with sepsis

It is very uncertain whether pentoxifylline with antibiotics (any dose or duration) changes periventricular leukomalacia compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates 2023 · Cochrane Headline outcomes only
RR 0.5 [0.1, 2.63]
1 study · 120 participants
Very low

Intervention not reported

Periventricular leukomalacia · preterm infants with low birth weight

The intervention probably leads to lower periventricular leukomalacia (moderate certainty).

1 finding from 1 review

Early erythropoiesis‐stimulating agents in preterm or low birth weight infants 2020 · Cochrane Headline outcomes only
RR 0.66 [0.48, 0.92]
6 studies · 1469 participants
Moderate

Cerebral NIRS oximetry vs no cerebral NIRS oximetry

Cystic periventricular leukomalacia (diagnosed by cranial ultrasound) · patients with preventing morbidity and mortality in very preterm infants

1 finding from 1 review

Cerebral near‐infrared spectroscopy monitoring for prevention of brain injury in very preterm infants 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 166 participants
Very low

Nasal interfaces (single nasal prong, binasal prongs (long or short), or nasal masks) vs face mask

Cranial ultrasound abnormalities (IVH grade ≥ 3 or cystic periventricular leukomalacia) · term and preterm infants resuscitated at birth, using positive pressure ventilation

It is very uncertain whether nasal interfaces (single nasal prong, binasal prongs (long or… changes cranial ultrasound abnormalities (IVH grade ≥ 3 or cystic… compared with face mask (very low certainty).

1 finding from 1 review

Nasal interfaces for neonatal resuscitation 2023 · Cochrane Headline outcomes only
RR 0.94 [0.55, 1.61]
3 studies · 749 participants
Very low