Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

9 questions · 9 findings · 8 reviews · All outcomes

No studies found 7 · 77.8%GRADE not reported 1 · 11.1%Very low 1 · 11.1%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Orthodontic treatment with appliances inducing stable, permanent orthodontic tooth movement (splints worn 8 to 12 weeks and surgical interventions excluded) vs Control: no treatment, placebo, or reassurance

Patient quality of life · Adults aged 18 years or older with clinically diagnosed TMD (exhibiting two or more of the listed signs and/or symptoms)

The review found no eligible studies for this question.

1 finding from 1 review

Any antifungal intervention for the treatment of oral candidiasis vs Placebo, no treatment, or another active antifungal intervention

Patient quality of life · Patients with cancer receiving chemotherapy and/or radiotherapy with overt oral candidiasis

The review found no eligible studies for this question.

1 finding from 1 review

Prophylactic aciclovir (oral or intravenous) vs placebo

Patient quality of life · Patients being treated for cancer (predominantly haematological malignancies)

The review found no eligible studies for this question.

1 finding from 1 review

Aciclovir (oral or intravenous) for treatment vs placebo

Patient quality of life · Patients being treated for cancer with established oral HSV infection (bone marrow transplant recipients / immunocompromised)

The review found no eligible studies for this question.

1 finding from 1 review

Antifungal drugs absorbed from GI tract (fluconazole, ketoconazole, itraconazole) vs placebo or no treatment

Patient quality of life · Patients with cancer receiving chemotherapy and/or radiotherapy

The review found no eligible studies for this question.

1 finding from 1 review

Experimental chewing adjuncts (bite wafers or chewing gum) vs No chewing gum, placebo, or control (no adjunct)

Quality of life or patient satisfaction · Adolescents/teenagers undergoing orthodontic treatment

Experimental chewing adjuncts (bite wafers or chewing gum) led to lower quality of life or patient satisfaction compared with no chewing gum, placebo, or control (no adjunct); GRADE not reported.

1 finding from 1 review

Chlorhexidine varnish vs placebo or no treatment

Pain, quality of life, patient satisfaction or costs · Children and adolescents below 18 years at study start (included studies: children from birth to 15 years), with mixed, permanent or…

The review found no eligible studies for this question.

1 finding from 1 review

Amifostine vs no treatment/placebo

Quality of life (Patient Benefit Questionnaire, 10-point scale) · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region

It is very uncertain whether amifostine changes quality of life (Patient Benefit Questionnaire, 10-point scale) compared with no treatment/placebo (very low certainty).

1 finding from 1 review