Findings

What do systematic reviews say?

5 questions · 5 findings · 1 reviews · Neonatal

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 20%Low 4 · 80%Moderate 0 · 0%High 0 · 0%

MFS‐LE vs S‐LE

Parenteral nutrition‐associated liver disease/cholestasis · Parenterally fed preterm infants

MFS‐LE showed no clear difference in parenteral nutrition‐associated liver disease/cholestasis compared with S‐LE (low certainty).

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
RR 3.32 [0.14, 78.25]
1 study · 57 participants
Low

MS‐LE vs S‐LE

Parenteral nutrition‐associated liver disease/cholestasis · Parenterally fed preterm infants

It is very uncertain whether MS‐LE changes parenteral nutrition‐associated liver disease/cholestasis compared with S‐LE (very low certainty).

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
RR 3 [0.13, 70.83]
1 study · 60 participants
Very low

Fish oil lipid emulsion (LE) vs S‐LE

Parenteral nutrition‐associated liver disease/cholestasis · Parenterally fed preterm infants

All fish oil containing LE showed no clear difference in parenteral nutrition‐associated liver disease/cholestasis compared with S‐LE (low certainty).

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
RR 0.8 [0.29, 2.16]
4 studies · 341 participants
Low

Alternative lipid emulsion (LE) vs S‐LE

Parenteral nutrition‐associated liver disease/cholestasis · Parenterally fed preterm infants

All alternative LE showed no clear difference in parenteral nutrition‐associated liver disease/cholestasis compared with S‐LE (low certainty).

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
RR 0.83 [0.37, 1.86]
7 studies · 602 participants
Low

MOFS‐LE vs S‐LE

Parenteral nutrition‐associated liver disease/cholestasis · Parenterally fed preterm infants

MOFS‐LE showed no clear difference in parenteral nutrition‐associated liver disease/cholestasis compared with S‐LE (low certainty).

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
RR 0.78 [0.29, 2.13]
4 studies · 314 participants
Low