Pain reduction (VAS 0-100) · People with erosive oral lichen planus
0.1% triamcinolone acetonide in orabase led to higher pain reduction (VAS 0-100) compared with ciclosporin solution; GRADE not reported.
1 finding from 1 review
Pain reduction (VAS 0-100) · People with erosive oral lichen planus
1 finding from 1 review
In the Hegarty 2002 cross-over trial (n=22), no statistical testing of the pain score (VAS 0 to 100) was reported; it is not clear whether the difference is statistically significant (fluticasone mean score 19.8 versus…
1 study · 22 participants
GRADE not reported
Pain reduction (VAS 0-100) · People with erosive oral lichen planus
Clobetasol-17-propionate 0.025% lipid-loaded microspheres led to lower pain reduction (VAS 0-100) compared with conventional 0.025% clobetasol lipophilic ointment in hydrophilic…; GRADE not reported.
1 finding from 1 review
Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
Analgesic (any: NSAID, paracetamol, local anaesthetic or opioid) probably leads to lower pain intensity (VAS 0-100 mm) compared with control (placebo or no treatment) (moderate certainty).
3 findings from 1 review
MD -11.66 [-16.15, -7.17]
10 studies · 685 participants
Moderate
MD -21.19 [-28.31, -14.06]
12 studies · 1012 participants
Moderate
MD -24.27 [-31.44, -17.11]
9 studies · 535 participants
Moderate
Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
It is very uncertain whether ibuprofen taken pre-emptively (about 1 hour before treatment) changes pain intensity (VAS 0-100 mm) compared with ibuprofen taken post-treatment (very low certainty).
3 findings from 1 review
MD -9.74 [-47.88, 28.40]
2 studies · 69 participants
Very low
MD -11.30 [-16.27, -6.33]
1 study · 41 participants
Very low
MD -8.43 [-30.37, 13.50]
2 studies · 69 participants
Very low
Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
NSAID (systemic) showed no clear difference in pain intensity (VAS 0-100 mm) compared with paracetamol (low certainty).
3 findings from 1 review
MD -5.17 [-11.71, 1.37]
7 studies · 664 participants
Low
MD -0.51 [-8.93, 7.92]
9 studies · 734 participants
Low
MD -2.92 [-8.48, 2.65]
7 studies · 664 participants
Low
Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
It is very uncertain whether topical NSAID (ketoprofen chewing gum) changes pain intensity (VAS 0-100 mm) compared with local anaesthetic (benzocaine chewing gum) (very low certainty).
1 finding from 1 review
Average pain scores (0-100 VAS) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis
Hypnosis showed no clear difference in average pain scores (0-100 VAS) compared with control (treatment as usual); GRADE not reported.
1 finding from 1 review
Average pain scores (0-100 VAS) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis
Diclofenac showed no clear difference in average pain scores (0-100 VAS) compared with placebo; GRADE not reported.
1 finding from 1 review
Average pain scores (0-100 VAS) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis
Relaxation and imagery training showed no clear difference in average pain scores (0-100 VAS) compared with control (treatment as usual); GRADE not reported.
1 finding from 1 review
Average pain scores (0-100 VAS) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis
Phenytoin mouthrinse showed no clear difference in average pain scores (0-100 VAS) compared with placebo; GRADE not reported.
1 finding from 1 review
Average pain scores (0-100 VAS) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis
Patient-controlled analgesia (PCA) pethidine showed no clear difference in average pain scores (0-100 VAS) compared with staff-controlled delivery of pethidine; GRADE not reported.
1 finding from 1 review
Average pain scores (0-100 VAS) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis
'Magic' mouthwash (lidocaine, diphenhydramine, aluminium hydroxide) showed no clear difference in average pain scores (0-100 VAS) compared with salt and soda mouthwash; GRADE not reported.
1 finding from 1 review
Average pain scores (0-100 VAS) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis
Sufentanil showed no clear difference in average pain scores (0-100 VAS) compared with morphine; GRADE not reported.
1 finding from 1 review
Average pain scores (0-100 VAS) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis
Therapist support (visits) showed no clear difference in average pain scores (0-100 VAS) compared with control (treatment as usual); GRADE not reported.
1 finding from 1 review
Average pain scores (0-100 VAS) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis
Chlorhexidine mouthwash showed no clear difference in average pain scores (0-100 VAS) compared with salt and soda mouthwash; GRADE not reported.
1 finding from 1 review
Average pain scores (0-100 VAS) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis
Alfentanil showed no clear difference in average pain scores (0-100 VAS) compared with morphine; GRADE not reported.
1 finding from 1 review
Average pain scores (0-100 VAS) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis
1 finding from 1 review
Average pain scores (0-100 VAS) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis
Cognitive behavioural therapy showed no clear difference in average pain scores (0-100 VAS) compared with control (treatment as usual); GRADE not reported.
1 finding from 1 review
Average pain scores (0-100 VAS) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis
Morphine via patient-controlled analgesia (PCA) showed no clear difference in average pain scores (0-100 VAS) compared with morphine via continuous infusion (CI); GRADE not reported.
1 finding from 1 review