What do systematic reviews say?

Adalimumab every other week vs placebo

• Interventions for hidradenitis suppurativa 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 21 participants
  Low

Topical clobetasol propionate 0.025% vs clobetasol cream 0.05% cream

Topical clobetasol propionate 0.025% showed no clear difference in pain reduction (VAS) compared with topical clobetasol propionate 0.05%; GRADE not reported.

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  MD -0.26 [-1.42, 0.90]
  1 study · 30 participants
  GRADE not reported

1% pimecrolimus cream vs Placebo (vehicle cream)

1% pimecrolimus cream showed no clear difference in pain reduction (VAS) compared with placebo (vehicle cream); GRADE not reported.

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  MD -3.30 [-20.22, 13.62]
  2 studies · 32 participants
  GRADE not reported

Tacrolimus 0.1% vs Topical clobetasol propionate 0.05% ointment

Topical tacrolimus 0.1% ointment showed no clear difference in pain reduction (VAS 0-10) compared with topical clobetasol propionate 0.05% ointment; GRADE not reported.

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  MD -0.64 [-1.91, 0.63]
  1 study · 29 participants
  GRADE not reported

Clobetasol propionate ointment vs 5% topical mesalazine gel in adhesive base

Clobetasol propionate ointment 0.05% showed no clear difference in pain reduction (VAS 0-10) compared with 5% topical mesalazine gel in adhesive base; GRADE not reported.

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  MD -0.83 [-4.12, 2.46]
  1 study · 12 participants
  GRADE not reported

Oral tetracycline vs topical clindamycin

• Interventions for hidradenitis suppurativa 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 34 participants
  Low

0.1% triamcinolone acetonide in orabase vs ciclosporin

0.1% triamcinolone acetonide in orabase led to higher pain reduction (VAS 0-100) compared with ciclosporin solution; GRADE not reported.

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  MD 45.17 [8.73, 81.61]
  1 study · 11 participants
  GRADE not reported

Fluticasone propionate spray vs Betamethasone sodium phosphate mouthwash

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  In the Hegarty 2002 cross-over trial (n=22), no statistical testing of the pain score (VAS 0 to 100) was reported; it is not clear whether the difference is statistically significant (fluticasone mean score 19.8 versus…
  1 study · 22 participants
  GRADE not reported

Clobetasol-17-propionate 0.025% lipid-loaded microspheres vs Clobetasol propionate 0.025% ointment

Clobetasol-17-propionate 0.025% lipid-loaded microspheres led to lower pain reduction (VAS 0-100) compared with conventional 0.025% clobetasol lipophilic ointment in hydrophilic…; GRADE not reported.

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  MD -18.30 [-28.57, -8.03]
  1 study · 45 participants
  GRADE not reported

Adalimumab weekly vs placebo

Adalimumab weekly probably leads to higher proportion with improvement in pain VAS compared with placebo (moderate certainty).

• Interventions for hidradenitis suppurativa 2015 · Cochrane Headline outcomes only
  RR 1.77 [1.02, 3.07]
  1 study · 96 participants
  Moderate

Pulsed dye laser vs Nd:YAG laser

• Interventions for rosacea 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 14 participants
  Low