Methotrexate vs alternative disease‐modifying antirheumatic drugs
Pain · children and young people with JIA
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Findings
What do systematic reviews say?
7 questions · 7 findings · 3 reviews · Musculoskeletal
No studies found 2 · 28.6%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 14.3%Moderate 3 · 42.9%High 1 · 14.3%
Methotrexate vs placebo
Pain on motion · children and young people with JIA
1 finding from 1 review
- no estimate extracted1 study · 114 participantsLow
Oral methotrexate plus intra‐articular glucocorticoid vs intra‐articular glucocorticoid alone
Pain · children and young people with JIA
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Summary of findings: leflunomide + methotrexate vs methotrexate
Change in pain (0‐100 mm VAS) · patients with rheumatoid arthritis in adults
1 finding from 1 review
- no estimate extracted1 study · 263 participantsHigh
Folic or folinic acid (any) vs placebo
Gastrointestinal adverse events · Patients receiving methotrexate for rheumatoid arthritis
Folic or folinic acid (any) probably leads to lower GI side effects (nausea, vomiting, abdominal pain) compared with placebo (moderate certainty).
1 finding from 1 review
- Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis 2013 · Cochrane Headline outcomes onlyRR 0.74 [0.59, 0.92]6 studies · 644 participantsModerate
Folinic acid vs placebo
Gastrointestinal adverse events · Patients receiving methotrexate for rheumatoid arthritis
Folinic acid showed no clear difference in GI side effects (nausea, vomiting, abdominal pain) compared with placebo (moderate certainty).
1 finding from 1 review
- Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis 2013 · Cochrane Headline outcomes onlyRR 0.78 [0.59, 1.02]4 studies · 426 participantsModerate
Summary of findings: Folic acid vs placebo
GI side effects (ie, incidence of nausea, vomiting, abdominal pain) · Patients receiving methotrexate for rheumatoid arthritis
Folic acid showed no clear difference in GI side effects (ie, incidence of nausea, vomiting, abdominal pain) compared with placebo (moderate certainty).
1 finding from 1 review
- Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis 2013 · Cochrane Headline outcomes onlyRR 0.76 [0.57, 1.01]3 studies · 355 participantsModerate