Summary of findings: Folic acid vs placebo: GI side effects (ie, incidence of nausea, vomiting, abdominal pain)
Folic acid showed no clear difference in GI side effects (ie, incidence of nausea, vomiting, abdominal pain) compared with placebo (moderate certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Folic acid vs placebo GI side effects (ie, incidence of nausea, vomiting, abdominal pain) · Patients receiving methotrexate for rheumatoid arthritis Folic acid showed no clear difference in GI side effects (ie, incidence of nausea, vomiting, abdominal pain) compared with placebo (moderate certainty). Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid… (2013) · Cochrane Headline outcomes only | RR 0.76 [0.57, 1.01] | 3 studies · 355 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis 2013 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.