Findings

What do systematic reviews say?

7 questions · 7 findings · 5 reviews · Haematology

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No studies found 2 · 28.6%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 14.3%Moderate 4 · 57.1%High 0 · 0%

ATRA in addition to chemotherapy vs chemotherapy alone

Mortality (calculated instead of overall survival) · adults with acute myeloid leukaemia (AML) (non‐acute promyelocytic leukaemia (APL))

ATRA in addition to chemotherapy showed no clear difference in mortality (instead of overall survival) compared with chemotherapy only (moderate certainty).

1 finding from 1 review

Effects of all‐trans retinoic acid (ATRA) in addition to chemotherapy for adults with acute myeloid leukaemia (AML)… 2018 · Cochrane Headline outcomes only
HR 0.94 [0.87, 1.02]
7 studies · 2985 participants
Moderate

Intervention not reported

Overall survival · people diagnosed with chemotherapy‐induced anemia

The review found no eligible studies for this question.

1 finding from 1 review

The role of iron in the management of chemotherapy‐induced anemia in cancer patients receiving… 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Overall survival ‐ not measured · patients with solid tumours with thrombocytopenia during chemotherapy

The review found no eligible studies for this question.

1 finding from 1 review

Thrombopoietin receptor agonists for prevention and treatment of chemotherapy‐induced thrombocytopenia in patients… 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Overall survival · Adult patients with follicular lymphoma

The intervention showed no clear difference in overall survival (moderate certainty).

1 finding from 1 review

High‐dose therapy with autologous stem cell transplantation versus chemotherapy or immuno‐chemotherapy for follicular… 2012 · Cochrane Headline outcomes only
HR 0.97 [0.76, 1.22]
3 studies · 701 participants
Moderate

Intervention not reported

Mortality (calculated instead of overall survival)

The intervention showed no clear difference in mortality (calculated instead of overall survival) (moderate certainty).

1 finding from 1 review

Chemotherapy alone versus chemotherapy plus radiotherapy for adults with early stage Hodgkin lymphoma 2017 · Cochrane Headline outcomes only
HR 0.48 [0.22, 1.06]
5 studies · 1388 participants
Moderate

Intervention not reported

Mortality (calculated instead of overall survival)

The intervention may leads to higher mortality (calculated instead of overall survival) (low certainty).

1 finding from 1 review

Chemotherapy alone versus chemotherapy plus radiotherapy for adults with early stage Hodgkin lymphoma 2017 · Cochrane Headline outcomes only
HR 2.12 [1.03, 4.37]
1 study · 276 participants
Low

Intervention not reported

Mortality sensitivity analysis (calculated instead of overall survival) ‐ without UK NCRI Rapid trial and MSKCC trial #90‐44due to high risk of other bias

The intervention probably leads to lower mortality sensitivity analysis (calculated instead of overall… (moderate certainty).

1 finding from 1 review

Chemotherapy alone versus chemotherapy plus radiotherapy for adults with early stage Hodgkin lymphoma 2017 · Cochrane Headline outcomes only
HR 0.31 [0.19, 0.52]
3 studies · 816 participants
Moderate