Cochrane · systematic review · CD007678
High‐dose therapy with autologous stem cell transplantation versus chemotherapy or immuno‐chemotherapy for follicular lymphoma in adults
Schaaf, M, Reiser, M, Borchmann, P, et al. · Cochrane Database of Systematic Reviews · 2012 · Cochrane Library
HaematologyAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 16.7%Low 2 · 33.3%Moderate 3 · 50%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: Adult patients with follicular lymphoma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall survival | HR 0.97 [0.76, 1.22] | 3 studies · 701 participants | Moderate Downgraded: inconsistency |
Treatment‐related mortality | RR 1.28 [0.25, 6.61] | 4 studies · 941 participants | Moderate Downgraded: risk of bias, inconsistency |
Progression‐free survival | HR 0.42 [0.33, 0.54] | 3 studies · 540 participants | Moderate Downgraded: risk of bias, inconsistency |
Secondary malignancies AML/MDS | RR 2.87 [0.7, 11.75] | 4 studies · 1023 participants | Low Downgraded: inconsistency |
Secondary malignancies Solid cancer | RR 1.2 [0.25, 5.77] | 3 studies · 701 participants | Low Downgraded: inconsistency |
Adverse events | no estimate extracted | 3 studies · 527 participants | Very low Downgraded: inconsistency |