Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

268 questions · 274 findings · 96 reviews

No studies found 24 · 8.8%GRADE not reported 11 · 4%Very low 27 · 9.9%Low 66 · 24.1%Moderate 96 · 35%High 50 · 18.2%

Intervention not reported

Overall survival · patients with extensive SCLC who relapsed or progressed after first‐line chemotherapy

The intervention may leads to lower overall survival (low certainty).

1 finding from 1 review

Single‐immune checkpoint inhibitors (ICIs) vs chemotherapy alone

Overall survival (OS) · People with advanced non‐small cell lung cancer

Single‐immune checkpoint inhibitors (ICIs) probably leads to lower overall survival (OS) compared with chemotherapy (moderate certainty).

1 finding from 1 review

Combined immune checkpoint inhibitors (ICIs) vs chemotherapy alone

Overall survival (OS) · People with advanced non‐small cell lung cancer

Combined immune checkpoint inhibitors (ICIs) probably leads to lower overall Survival (OS) compared with chemotherapy (moderate certainty).

1 finding from 1 review

Neoadjuvant immunotherapy (talimogene laherparepvec) vs no neoadjuvant treatment

Death Number of deaths over 36 months · stage III and IV cutaneous melanoma

It is very uncertain whether neoadjuvant immunotherapy (talimogene laherparepvec) changes overall survival (OS), measured by the number of deaths over time, compared with no neoadjuvant treatment (very low certainty).

1 finding from 1 review

Bortezomib vs no bortezomib

Overall Survival ‐ Bortezomib versus no bortezomib (same background therapy) · All patients with a diagnosis of multiple myeloma

Bortezomib probably leads to lower overall Survival ‐ Bortezomib versus no bortezomib (same background… compared with no bortezomib (moderate certainty).

1 finding from 1 review

Intervention not reported

Overall survival: 2‐year survival rate · stages I to III NSCLC patients treated with surgery or radiotherapy with curative intent

The intervention showed no clear difference in overall survival: 2‐year survival rate (moderate certainty).

1 finding from 1 review

Intervention not reported

Overall survival: 3‐year survival rate · stages I to III NSCLC patients treated with surgery or radiotherapy with curative intent

The intervention showed no clear difference in overall survival: 3‐year survival rate (moderate certainty).

1 finding from 1 review

Intervention not reported

Overall survival: 5‐year survival rate · stages I to III NSCLC patients treated with surgery or radiotherapy with curative intent

The intervention showed no clear difference in overall survival: 5‐year survival rate (moderate certainty).

1 finding from 1 review