Findings

What do systematic reviews say?

7 questions · 7 findings · 4 reviews

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No studies found 2 · 28.6%GRADE not reported 0 · 0%Very low 0 · 0%Low 4 · 57.1%Moderate 1 · 14.3%High 0 · 0%

Apatinib plus chemotherapy or chemotherapy/brachytherapy vs chemotherapy or chemotherapy/brachytherapy

Overall survival · women with recurrent or FIGO stage IVB cervical cancer

Apatinib plus chemotherapy or chemotherapy/brachytherapy showed no clear difference in overall survival compared with chemotherapy or chemotherapy/brachytherapy (low certainty).

1 finding from 1 review

Vascular endothelial growth factor (VEGF) targeting therapy for persistent, recurrent, or metastatic cervical cancer 2021 · Cochrane Headline outcomes only
HR 0.9 [0.51, 1.6]
1 study · 52 participants
Low

Pre-radiotherapy extraction of healthy molar teeth vs Conservative treatment (leaving the teeth in place during radiotherapy, with oral health education and disease prevention: oral hygiene, fluoride, diet advice)

Overall survival · Patients diagnosed with head and neck cancer planned to undergo any type of radiotherapy (external beam, intensity modulated,…

The review found no eligible studies for this question.

1 finding from 1 review

Dental extractions prior to radiotherapy to the jaws for reducing post‐radiotherapy dental complications 2013 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Pre-radiotherapy extraction of diseased molar teeth vs Conservative treatment (restoration of the teeth and leaving them in place during radiotherapy, with oral health education and disease prevention: oral hygiene, fluoride, diet advice)

Overall survival · Patients diagnosed with head and neck cancer planned to undergo any type of radiotherapy (external beam, intensity modulated,…

The review found no eligible studies for this question.

1 finding from 1 review

Dental extractions prior to radiotherapy to the jaws for reducing post‐radiotherapy dental complications 2013 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Hysterectomy (simple or radical) with chemoradiotherapy vs internal radiotherapy (brachytherapy) with chemoradiotherapy

Death (all causes) · women with locally advanced cervical cancer

Hysterectomy (simple or radical) with chemoradiotherapy showed no clear difference in overall survival Median compared with internal radiotherapy (brachytherapy) with chemoradiotherapy (low certainty).

1 finding from 1 review

Hysterectomy with radiotherapy or chemotherapy or both for women with locally advanced cervical cancer 2022 · Cochrane Headline outcomes only
HR 0.65 [0.35, 1.21]
1 study · 211 participants
Low

Intervention not reported

5‐year overall survival rate (3 to 6 yr) · women with locally advanced uterine cervix cancer

The intervention showed no clear difference in 5‐year overall survival rate (3 to 6 yr) (low certainty).

1 finding from 1 review

High dose rate versus low dose rate intracavity brachytherapy for locally advanced uterine cervix cancer 2014 · Cochrane Headline outcomes only
RR 0.93 [0.84, 1.04]
2 studies · 912 participants
Low

Intervention not reported

10‐year overall survival rate (5 to 15 yr) · women with locally advanced uterine cervix cancer

The intervention showed no clear difference in 10‐year overall survival rate (5 to 15 yr) (moderate certainty).

1 finding from 1 review

High dose rate versus low dose rate intracavity brachytherapy for locally advanced uterine cervix cancer 2014 · Cochrane Headline outcomes only
RR 0.79 [0.52, 1.2]
1 study · 430 participants
Moderate

Intervention not reported

3‐year overall survival rate (37.2/40.2 mo) · women with locally advanced uterine cervix cancer

The intervention showed no clear difference in 3‐year overall survival rate (37.2/40.2 mo) (low certainty).

1 finding from 1 review

High dose rate versus low dose rate intracavity brachytherapy for locally advanced uterine cervix cancer 2014 · Cochrane Headline outcomes only
RR 0.95 [0.79, 1.15]
1 study · 206 participants
Low