Findings

What do systematic reviews say?

3 questions · 4 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 4 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Antidepressant plus antipsychotic vs placebo/no adjunctive treatment + antipsychotics

Leaving the study early · adults with psychotic depression

It is very uncertain whether antidepressant plus antipsychotic changes overall dropouts compared with placebo plus antipsychotic (very low certainty).

1 finding from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
RR 0.79 [0.63, 1.01]
4 studies · 447 participants
Very low

Antidepressant plus antipsychotic vs placebo plus antidepressant

Leaving the study early · adults with psychotic depression

It is very uncertain whether antidepressant plus antipsychotic changes overall dropouts compared with placebo plus antidepressant (very low certainty).

2 findings from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
RR 0.91 [0.55, 1.5]
4 studies · 245 participants
Very low
Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
RR 1.04 [0.52, 2.07]
3 studies · 157 participants
Very low

Antidepressant plus antipsychotic vs placebo

Leaving the study early · adults with psychotic depression

It is very uncertain whether antidepressant plus antipsychotic changes overall dropouts compared with placebo (very low certainty).

1 finding from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
RR 0.75 [0.48, 1.18]
2 studies · 148 participants
Very low