Findings

What do systematic reviews say?

8 questions · 14 findings · 1 reviews · Oral Health

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No studies found 0 · 0%GRADE not reported 14 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS

Osteoporosis with pathological fracture · European GWAS participants

The SVMR MR-Egger interval included the null.

3 findings from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · SVMR MR-Egger
OR 1.097 [0.598, 2.011]
376746 participants
GRADE not reported
From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · SVMR Weighted Median
OR 1.181 [0.748, 1.866]
376746 participants
GRADE not reported
From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · SVMR Maximum Likelihood
OR 1.278 [0.921, 1.773]
376746 participants
GRADE not reported

Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS, adjusted for periodontitis

Osteoporosis with pathological fracture · European GWAS participants

The MVMR MR-Egger interval included the null.

1 finding from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · MVMR MR-Egger
OR 1.011 [0.876, 1.167]
376746 participants
GRADE not reported

Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS

Postmenopausal osteoporosis with pathological fracture · European GWAS participants

The SVMR Maximum Likelihood interval included the null.

3 findings from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · SVMR Maximum Likelihood
OR 1.363 [0.955, 1.947]
281786 participants
GRADE not reported
From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · SVMR MR-Egger
OR 1.355 [0.696, 2.635]
281786 participants
GRADE not reported
From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · SVMR Weighted Median
OR 1.214 [0.746, 1.977]
281786 participants
GRADE not reported

Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS, adjusted for periodontitis

Postmenopausal osteoporosis with pathological fracture · European GWAS participants

The MVMR MR-Egger interval included the null.

1 finding from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · MVMR MR-Egger
OR 1.281 [0.640, 2.565]
281786 participants
GRADE not reported

Genetically predicted DMFS (dental caries) vs Reference (1-SD lower genetically predicted DMFS)

Osteoporosis with pathological fracture · European-ancestry adults

In multivariable MR, genetically predicted dental caries (DMFS) had no significant causal effect on osteoporosis with pathological fracture (OR 1.279, not significant).

2 findings from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Lifelong genetic liability · European-ancestry population (two-sample MR: GLIDE exposures; FinnGen osteoporosis/fractures; GeFOS BMD) · MVMR (IVW), adjusted for periodontitis
OR 1.279 [0.955, 1.713]
376746 participants
GRADE not reported
From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Lifelong genetic liability · European-ancestry population (two-sample MR: GLIDE exposures; FinnGen osteoporosis/fractures; GeFOS BMD) · SVMR (IVW), total causal effect
OR 1.261 [0.918, 1.732]
376746 participants
GRADE not reported

Genetically predicted DMFS (dental caries) vs Reference (1-SD lower genetically predicted DMFS)

Postmenopausal osteoporosis with pathological fracture · Postmenopausal women (European ancestry)

In multivariable MR (adjusted for periodontitis), genetically predicted dental caries (DMFS) causally increased postmenopausal osteoporosis with pathological fracture (OR 1.422, moderate evidence).

2 findings from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Lifelong genetic liability · European-ancestry population (two-sample MR: GLIDE exposures; FinnGen osteoporosis/fractures; GeFOS BMD) · MVMR (IVW), adjusted for periodontitis
OR 1.422 [1.027, 1.969]
281786 participants
GRADE not reported
From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Lifelong genetic liability · European-ancestry population (two-sample MR: GLIDE exposures; FinnGen osteoporosis/fractures; GeFOS BMD) · SVMR (IVW), total causal effect
OR 1.343 [0.948, 1.901]
281786 participants
GRADE not reported

Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability, adjusted for DMFS

Osteoporosis with pathological fracture · European GWAS participants

The MVMR MR-Egger interval included the null.

1 finding from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · MVMR MR-Egger
OR 1.002 [0.867, 1.158]
376746 participants
GRADE not reported

Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability, adjusted for DMFS

Postmenopausal osteoporosis with pathological fracture · European GWAS participants

The MVMR MR-Egger interval included the null.

1 finding from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · MVMR MR-Egger
OR 1.012 [0.858, 1.193]
281786 participants
GRADE not reported