Osteoporosis · European GWAS participants
The MVMR MR-Egger interval excluded the null.
1 finding from 1 review
OR 1.343 [1.015, 1.778]
483725 participants
GRADE not reported
Osteoporosis · European GWAS participants
The SVMR Weighted Median interval excluded the null.
3 findings from 1 review
OR 1.260 [1.017, 1.560]
483725 participants
GRADE not reported
OR 1.162 [0.998, 1.353]
483725 participants
GRADE not reported
OR 1.329 [0.991, 1.782]
483725 participants
GRADE not reported
Osteoporosis · European-ancestry adults
In multivariable MR (adjusted for periodontitis), higher genetically predicted dental caries (DMFS) causally increased osteoporosis risk (OR 1.165, moderate evidence).
2 findings from 1 review
Osteoporosis with pathological fracture · European GWAS participants
The SVMR MR-Egger interval included the null.
3 findings from 1 review
OR 1.097 [0.598, 2.011]
376746 participants
GRADE not reported
OR 1.181 [0.748, 1.866]
376746 participants
GRADE not reported
OR 1.278 [0.921, 1.773]
376746 participants
GRADE not reported
Osteoporosis with pathological fracture · European GWAS participants
The MVMR MR-Egger interval included the null.
1 finding from 1 review
OR 1.011 [0.876, 1.167]
376746 participants
GRADE not reported
Osteoporosis with pathological fracture · European-ancestry adults
In multivariable MR, genetically predicted dental caries (DMFS) had no significant causal effect on osteoporosis with pathological fracture (OR 1.279, not significant).
2 findings from 1 review
Postmenopausal osteoporosis with pathological fracture · European GWAS participants
The SVMR Maximum Likelihood interval included the null.
3 findings from 1 review
OR 1.363 [0.955, 1.947]
281786 participants
GRADE not reported
OR 1.355 [0.696, 2.635]
281786 participants
GRADE not reported
OR 1.214 [0.746, 1.977]
281786 participants
GRADE not reported
Postmenopausal osteoporosis with pathological fracture · European GWAS participants
The MVMR MR-Egger interval included the null.
1 finding from 1 review
OR 1.281 [0.640, 2.565]
281786 participants
GRADE not reported
Postmenopausal osteoporosis with pathological fracture · Postmenopausal women (European ancestry)
In multivariable MR (adjusted for periodontitis), genetically predicted dental caries (DMFS) causally increased postmenopausal osteoporosis with pathological fracture (OR 1.422, moderate evidence).
2 findings from 1 review
Osteoporosis · European GWAS participants
The SVMR MR-Egger interval included the null.
4 findings from 1 review
OR 1.001 [0.918, 1.093]
483725 participants
GRADE not reported
OR 0.998 [0.934, 1.067]
483725 participants
GRADE not reported
OR 1.002 [0.925, 1.086]
483725 participants
GRADE not reported
Show 1 more finding
OR 0.998 [0.933, 1.067]
483725 participants
GRADE not reported
Osteoporosis · European-ancestry adults
Genetically predicted periodontitis had no causal effect on osteoporosis (multivariable MR, OR 1.000).
2 findings from 1 review
Osteoporosis · European GWAS participants
The MVMR MR-Egger interval included the null.
1 finding from 1 review
OR 1.005 [0.940, 1.074]
483725 participants
GRADE not reported
Intervention not reported
Osteoporosis
The intervention led to higher osteoporosis; GRADE not reported.
1 finding from 1 review
OR 1.171 [1.051, 1.304]
Studies not reported
GRADE not reported
Osteoporosis with pathological fracture · European GWAS participants
The SVMR Weighted Median interval included the null.
3 findings from 1 review
OR 0.985 [0.846, 1.146]
376746 participants
GRADE not reported
OR 1.003 [0.874, 1.151]
376746 participants
GRADE not reported
OR 0.953 [0.813, 1.117]
376746 participants
GRADE not reported
Osteoporosis with pathological fracture · European-ancestry adults
Genetically predicted periodontitis had no causal effect on osteoporosis with pathological fracture (single-variable MR, OR 1.003).
2 findings from 1 review
Osteoporosis with pathological fracture · European GWAS participants
The MVMR MR-Egger interval included the null.
1 finding from 1 review
OR 1.002 [0.867, 1.158]
376746 participants
GRADE not reported
Intervention not reported
Postmenopausal osteoporosis with pathological fracture
The intervention led to higher postmenopausal osteoporosis with pathological fracture; GRADE not reported.
1 finding from 1 review
OR 1.401 [1.040, 1.887]
Studies not reported
GRADE not reported
Postmenopausal osteoporosis with pathological fracture · European GWAS participants
The MVMR MR-Egger interval included the null.
1 finding from 1 review
OR 1.012 [0.858, 1.193]
281786 participants
GRADE not reported
Postmenopausal osteoporosis with pathological fracture · European GWAS participants
The SVMR Weighted Median interval included the null.
3 findings from 1 review
OR 0.979 [0.826, 1.159]
281786 participants
GRADE not reported
OR 1.014 [0.872, 1.179]
281786 participants
GRADE not reported
OR 0.934 [0.786, 1.111]
281786 participants
GRADE not reported
Postmenopausal osteoporosis with pathological fracture · Postmenopausal women (European ancestry)
Genetically predicted periodontitis had no causal effect on postmenopausal osteoporosis with pathological fracture (single-variable MR, OR 1.014).
2 findings from 1 review