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Evidence found and GRADE certainty

4 questions · 4 findings · 3 reviews · Oral medicine and oral cancer

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No studies found 0 · 0%GRADE not reported 2 · 50%Very low 1 · 25%Low 1 · 25%Moderate 0 · 0%High 0 · 0%

Chlorhexidine vs Cryotherapy (ice chips) 60 minutes

Oral mucositis (any severity) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Chlorhexidine showed no clear difference in oral mucositis (any severity) compared with cryotherapy (ice chips); GRADE not reported.

1 finding from 1 review

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs Chlorhexidine mouthwash

Oral mucositis (any severity) · Children with acute lymphoblastic leukaemia receiving chemotherapy alone

Keratinocyte growth factor (KGF), intravenous led to lower oral mucositis (any severity) compared with chlorhexidine mouthwash; GRADE not reported.

1 finding from 1 review

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs Chlorhexidine rinse

Oral mucositis (any severity) · Adults with solid cancers receiving fluorouracil (5FU) and leucovorin

It is very uncertain whether oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed… changes oral mucositis (any severity) compared with chlorhexidine rinse (very low certainty).

1 finding from 1 review