What do systematic reviews say?

Gonadotrophins with anti‐oestrogens vs gonadotropins alone

Gonadotrophins with anti‐oestrogens showed no clear difference in OHSS rate per couple compared with gonadotropins alone (low certainty).

• Agents for ovarian stimulation for intrauterine insemination (IUI) in ovulatory women with infertility 2021 · Cochrane Headline outcomes only
  OR 0.5 [0.04, 5.54]
  1 study · 230 participants
  Low

Aromatase inhibitors vs anti‐oestrogens

• Agents for ovarian stimulation for intrauterine insemination (IUI) in ovulatory women with infertility 2021 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 813 participants
  Moderate

Aromatase inhibitors with gonadotropins vs anti‐oestrogens with gonadotropins

Aromatase inhibitors with gonadotropins showed no clear difference in OHSS rate per couple compared with anti‐oestrogens with gonadotropins (low certainty).

• Agents for ovarian stimulation for intrauterine insemination (IUI) in ovulatory women with infertility 2021 · Cochrane Headline outcomes only
  OR 4.45 [0.75, 26.43]
  4 studies · 901 participants
  Low

Gonadotropins vs anti‐oestrogens

Gonadotropins showed no clear difference in OHSS rate per couple compared with anti‐oestrogens (low certainty).

• Agents for ovarian stimulation for intrauterine insemination (IUI) in ovulatory women with infertility 2021 · Cochrane Headline outcomes only
  OR 0.77 [0.19, 3.14]
  6 studies · 1482 participants
  Low