What do systematic reviews say?

Aromatase inhibitors vs anti‐oestrogens

• Agents for ovarian stimulation for intrauterine insemination (IUI) in ovulatory women with infertility 2021 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 813 participants
  Moderate

Gonadotropins with GnRH agonists vs gonadotropins alone

It is very uncertain whether gonadotropins with GnRH agonists changes OHSS rate per couple compared with gonadotropins alone (very low certainty).

• Agents for ovarian stimulation for intrauterine insemination (IUI) in ovulatory women with infertility 2021 · Cochrane Headline outcomes only
  OR 1.8 [0.39, 8.32]
  1 study · 60 participants
  Very low

Gonadotropins with GnRH antagonist vs gonadotropins alone

It is very uncertain whether gonadotropins with GnRH antagonist changes OHSS rate per couple compared with gonadotropins alone (very low certainty).

• Agents for ovarian stimulation for intrauterine insemination (IUI) in ovulatory women with infertility 2021 · Cochrane Headline outcomes only
  OR 0.98 [0.12, 8.32]
  5 studies · 1348 participants
  Very low

Gonadotrophins with anti‐oestrogens vs gonadotropins alone

Gonadotrophins with anti‐oestrogens showed no clear difference in OHSS rate per couple compared with gonadotropins alone (low certainty).

• Agents for ovarian stimulation for intrauterine insemination (IUI) in ovulatory women with infertility 2021 · Cochrane Headline outcomes only
  OR 0.5 [0.04, 5.54]
  1 study · 230 participants
  Low

Aromatase inhibitors vs gonadotropins alone

Aromatase inhibitors showed no clear difference in OHSS rate per couple compared with gonadotropins (low certainty).

• Agents for ovarian stimulation for intrauterine insemination (IUI) in ovulatory women with infertility 2021 · Cochrane Headline outcomes only
  OR 1 [0.14, 7.2]
  2 studies · 680 participants
  Low

Aromatase inhibitors with gonadotropins vs anti‐oestrogens with gonadotropins

Aromatase inhibitors with gonadotropins showed no clear difference in OHSS rate per couple compared with anti‐oestrogens with gonadotropins (low certainty).

• Agents for ovarian stimulation for intrauterine insemination (IUI) in ovulatory women with infertility 2021 · Cochrane Headline outcomes only
  OR 4.45 [0.75, 26.43]
  4 studies · 901 participants
  Low

Gonadotropins vs anti‐oestrogens

Gonadotropins showed no clear difference in OHSS rate per couple compared with anti‐oestrogens (low certainty).

• Agents for ovarian stimulation for intrauterine insemination (IUI) in ovulatory women with infertility 2021 · Cochrane Headline outcomes only
  OR 0.77 [0.19, 3.14]
  6 studies · 1482 participants
  Low