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What do systematic reviews say?

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Evidence found and GRADE certainty

14 questions · 14 findings · 1 reviews

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No studies found 4 · 28.6%GRADE not reported 0 · 0%Very low 3 · 21.4%Low 4 · 28.6%Moderate 3 · 21.4%High 0 · 0%

Tramadol vs paracetamol

Number of participants reporting an adverse event · patients with osteoarthritis

The review found no eligible studies for this question.

1 finding from 1 review

Tramadol vs NSAIDs

Number of participants reporting an adverse event · patients with osteoarthritis

Tramadol alone probably leads to higher number of participants experiencing any adverse event compared with NSAIDs (moderate certainty).

1 finding from 1 review

Tramadol vs other opioids

Number of participants reporting an adverse event · patients with osteoarthritis

It is very uncertain whether tramadol alone changes number of participants experiencing any adverse event compared with other opioids (very low certainty).

1 finding from 1 review

Tramadol vs placebo

Number experiencing adverse effects · Patients with osteoarthritis of the knee or hip

Tramadol alone probably leads to higher number of participants experiencing any adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Tramadol vs paracetamol

Number of participants experiencing any serious adverse events · patients with osteoarthritis

The review found no eligible studies for this question.

1 finding from 1 review

Tramadol vs NSAIDs

Number of participants experiencing any serious adverse events · patients with osteoarthritis

It is very uncertain whether tramadol alone changes number of participants experiencing any serious adverse events compared with NSAIDs (very low certainty).

1 finding from 1 review

Tramadol vs other opioids

Number of participants experiencing any serious adverse events · patients with osteoarthritis

It is very uncertain whether tramadol alone changes number of participants experiencing any serious adverse events compared with other opioids (very low certainty).

1 finding from 1 review

Tramadol vs placebo

Number of participants experiencing any serious adverse events · Patients with osteoarthritis of the knee or hip

Tramadol alone may leads to higher number of participants experiencing any serious adverse events compared with placebo (low certainty).

1 finding from 1 review

Tramadol in combination with acetaminophen vs placebo

Number of participants reporting an adverse event · patients with osteoarthritis

Tramadol in combination with acetaminophen probably leads to higher number of participants experiencing any adverse event compared with placebo (moderate certainty).

1 finding from 1 review

Tramadol in combination with acetaminophen vs NSAIDs

Number of participants reporting an adverse event · patients with osteoarthritis

Tramadol in combination with acetaminophen showed no clear difference in number of participants experiencing any adverse event compared with NSAIDs (low certainty).

1 finding from 1 review