What do systematic reviews say?

Oral misoprostol vs vaginal misoprostol

Oral misoprostol may leads to higher nausea compared with vaginal misoprostol (low certainty).

• Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
  RR 1.14 [1.03, 1.26]
  2 studies · 1380 participants
  Low
• Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
  RR 1.21 [0.92, 1.61]
  2 studies · 216 participants
  Low

Misoprostol vs surgery

Misoprostol may leads to higher nausea compared with surgery (low certainty).

• Medical treatments for incomplete miscarriage 2017 · Cochrane Headline outcomes only
  RR 2.5 [1.53, 4.09]
  11 studies · 3015 participants
  Low

Misoprostol vs expectant care

• Medical treatments for incomplete miscarriage 2017 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Sublingual misoprostol vs vaginal misoprostol

Sublingual misoprostol showed no clear difference in nausea compared with vaginal misoprostol (moderate certainty).

• Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
  RR 1.11 [0.93, 1.33]
  3 studies · 3543 participants
  Moderate

Sublingual misoprostol vs vaginal misoprostol

Sublingual misoprostol alone showed no clear difference in nausea compared with vaginal misoprostol alone (low certainty).

• Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
  RR 1.61 [0.78, 3.33]
  4 studies · 2505 participants
  Low

Misoprostol 800 µg plus mifepristone 200 mg vs mifepristone (200 mg) plus prostaglandin

Misoprostol 800 µg plus mifepristone 200 mg showed no clear difference in nausea compared with misoprostol 400 µg plus mifepristone 200 mg (moderate certainty).

• Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
  RR 0.99 [0.94, 1.05]
  3 studies · 4424 participants
  Moderate

Vaginal misoprostol vs surgical evacuation of uterus

Vaginal misoprostol may leads to higher nausea compared with surgical evacuation of uterus (low certainty).

• Medical treatment for early fetal death (less than 24 weeks) 2019 · Cochrane Headline outcomes only
  RR 21.85 [1.31, 364.37]
  1 study · 154 participants
  Low

Vaginal misoprostol vs placebo

Vaginal misoprostol showed no clear difference in nausea compared with placebo (low certainty).

• Medical treatment for early fetal death (less than 24 weeks) 2019 · Cochrane Headline outcomes only
  RR 1.38 [0.43, 4.4]
  2 studies · 88 participants
  Low