Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

11 questions · 11 findings · 7 reviews · Heart

No studies found 2 · 18.2%GRADE not reported 0 · 0%Very low 2 · 18.2%Low 1 · 9.1%Moderate 4 · 36.4%High 2 · 18.2%

Homocysteine‐lowering interventions (high dose) vs homocysteine‐lowering interventions (low dose)

Myocardial infarction · people with or without existing cardiovascular disease, men and women

Homocysteine‐lowering interventions (high dose) showed no clear difference in myocardial infarction compared with homocysteine‐lowering interventions (low dose) (moderate certainty).

1 finding from 1 review

Intervention not reported

Myocardial infarction (non‐fatal) · people with cardiovascular disease or at high risk of cardiovascular disease

The intervention probably leads to lower myocardial infarction (non‐fatal) (moderate certainty).

1 finding from 1 review

clopidogrel plus aspirin vs aspirin

Fatal or nonfatal myocardial infarction · people with coronary disease, ischaemic cerebrovascular disease, peripheral arterial disease or at high risk of atherothrombotic disease

clopidogrel plus aspirin probably leads to lower fatal and non‐fatal myocardial infarction compared with aspirin alone (moderate certainty).

1 finding from 1 review