Findings

What do systematic reviews say?

25 questions · 26 findings · 7 reviews

No studies found 4 · 15.4%GRADE not reported 0 · 0%Very low 12 · 46.2%Low 9 · 34.6%Moderate 1 · 3.8%High 0 · 0%

Multiple pregnancy rate · women trying to conceive by intrauterine insemination

It is very uncertain whether hCG changes multiple pregnancy rate per pregnancy compared with LH surge (very low certainty).

1 finding from 1 review

Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
OR 1.12 [0.17, 7.6]
2 studies · 42 participants
Very low

Multiple pregnancy rate · women trying to conceive by intrauterine insemination

u‐hCG showed no clear difference in multiple pregnancy rate per pregnancy compared with r‐hCG (low certainty).

1 finding from 1 review

Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
OR 0.99 [0.4, 2.47]
2 studies · 109 participants
Low

Multiple pregnancy rate · women with gonadotropin stimulation

Progesterone showed no clear difference in multiple pregnancy rate compared with placebo/no treatment (low certainty).

1 finding from 1 review

Multiple pregnancy rate · women with gonadotropin plus oral (clomiphene citrate or letrozole) stimulation

Progesterone showed no clear difference in multiple pregnancy rate compared with placebo/no treatment (low certainty).

1 finding from 1 review

Multiple pregnancy rate · subfertile women with polycystic ovary syndrome

Metformin showed no clear difference in multiple pregnancy rate (per woman) compared with placebo co‐treatment (low certainty).

1 finding from 1 review