Findings

What do systematic reviews say?

5 questions · 5 findings · 3 reviews · Gynaecology and Fertility

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No studies found 1 · 20%GRADE not reported 0 · 0%Very low 1 · 20%Low 2 · 40%Moderate 1 · 20%High 0 · 0%

Ultrasound‐guided embryo transfer vs clinical touch

Multiple pregnancy rate · Women undergoing embryo transfer as part of IVF or ICSI cycle

Ultrasound‐guided embryo transfer showed no clear difference in multiple pregnancy (per woman randomised) compared with clinical touch (moderate certainty).

1 finding from 1 review

Ultrasound versus 'clinical touch' for catheter guidance during embryo transfer in women 2016 · Cochrane Headline outcomes only
OR 1.13 [0.87, 1.45]
8 studies · 3379 participants
Moderate

IVF vs IUI + ovarian stimulation with gonadotropins or CC

Multiple pregnancy rate · women with unexplained subfertility

IVF showed no clear difference in multiple pregnancy rate per woman randomised compared with IUI + ovarian stimulation with gonadotropins or CC (low certainty).

1 finding from 1 review

In vitro fertilisation for unexplained subfertility 2023 · Cochrane Headline outcomes only
OR 0.82 [0.38, 1.77]
3 studies · 731 participants
Low

IVF vs expectant management

Multiple pregnancy rate · women with unexplained subfertility

The review found no eligible studies for this question.

1 finding from 1 review

In vitro fertilisation for unexplained subfertility 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

IVF vs unstimulated IUI

Multiple pregnancy rate · women with unexplained subfertility

It is very uncertain whether IVF changes multiple pregnancy rate per woman randomised compared with unstimulated IUI (very low certainty).

1 finding from 1 review

In vitro fertilisation for unexplained subfertility 2023 · Cochrane Headline outcomes only
OR 1.03 [0.04, 27.29]
1 study · 43 participants
Very low

Assisted hatching vs no assisted hatching

Multiple pregnancy rate · women undergoing assisted reproduction

Assisted hatching may leads to higher multiple pregnancy rate per woman randomised compared with no assisted hatching (low certainty).

1 finding from 1 review

Assisted hatching on assisted conception (in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI)) 2021 · Cochrane Headline outcomes only
OR 1.38 [1.13, 1.68]
18 studies · 4308 participants
Low