Findings

What do systematic reviews say?

7 questions · 7 findings · 3 reviews · Neonatal

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 14.3%Low 3 · 42.9%Moderate 1 · 14.3%High 2 · 28.6%

Higher dose vitamin K vs lower dose vitamin K

Mortality (all infants): 0.2 mg IM versus 0.5 mg IM · preterm infants

Higher dose vitamin K showed no clear difference in mortality (all infants): 0.2 mg IM versus 0.5 mg IM compared with lower dose vitamin K (low certainty).

1 finding from 1 review

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
RR 2.13 [0.6, 7.51]
1 study · 65 participants
Low

Intramuscular vitamin K vs intravenous vitamin K

Mortality (all infants): 0.2 mg IV versus 0.2 mg IM · preterm infants

Intramuscular vitamin K showed no clear difference in mortality (all infants): 0.2 mg IV versus 0.2 mg IM compared with intravenous vitamin K (low certainty).

1 finding from 1 review

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
RR 1.32 [0.56, 3.14]
1 study · 67 participants
Low

Intramuscular vitamin K vs intravenous vitamin K

Mortality (all infants): 0.2 mg IV versus 0.5 mg IM · preterm infants

Intramuscular vitamin K showed no clear difference in mortality (all infants): 0.2 mg IV versus 0.5 mg IM compared with intravenous vitamin K (low certainty).

1 finding from 1 review

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
RR 2.82 [0.84, 9.46]
1 study · 64 participants
Low

Neonatal vitamin A supplementation vs control

Neonatal mortality · mortality and morbidity in term neonates

Neonatal vitamin A supplementation showed no clear difference in all‐cause neonatal mortality: risk ratios based on cumulative risk… compared with control (high certainty).

1 finding from 1 review

Neonatal vitamin A supplementation for the prevention of mortality and morbidity in term neonates in low and middle… 2017 · Cochrane Headline outcomes only
RR 0.99 [0.9, 1.08]
5 studies · 126242 participants
High

Neonatal vitamin A supplementation vs control

Infant Mortality at 6 Months · mortality and morbidity in term neonates

Neonatal vitamin A supplementation showed no clear difference in all‐cause infant mortality at 6 months: risk ratios based on… compared with control (high certainty).

1 finding from 1 review

Neonatal vitamin A supplementation for the prevention of mortality and morbidity in term neonates in low and middle… 2017 · Cochrane Headline outcomes only
RR 0.98 [0.89, 1.07]
11 studies · 154634 participants
High

Neonatal vitamin A supplementation vs control

All‐cause infant mortality at 6 months: risk ratios based on cumulative risk (%, adjusted for clustering) ‐ term infants · mortality and morbidity in term neonates

It is very uncertain whether neonatal vitamin A supplementation changes all‐cause infant mortality at 6 months: risk ratios based on… compared with control (very low certainty).

1 finding from 1 review

Neonatal vitamin A supplementation for the prevention of mortality and morbidity in term neonates in low and middle… 2017 · Cochrane Headline outcomes only
RR 0.8 [0.54, 1.18]
3 studies · 22721 participants
Very low

Intervention not reported

All‐cause mortality: longest · infants 1 to 6 months of age

The intervention showed no clear difference in all‐cause mortality: longest (moderate certainty).

1 finding from 1 review

Vitamin A supplementation for the prevention of morbidity and mortality in infants one to six months of age 2016 · Cochrane Headline outcomes only
RR 1.05 [0.89, 1.25]
9 studies · 21339 participants
Moderate