Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

54 questions · 55 findings · 15 reviews

No studies found 20 · 36.4%GRADE not reported 0 · 0%Very low 9 · 16.4%Low 14 · 25.5%Moderate 12 · 21.8%High 0 · 0%

Slow vs faster rates of enteral feed advancement

Mortality before hospital discharge · very preterm or very low birth weight infants

Slow showed no clear difference in mortality before hospital discharge compared with faster rates of enteral feed advancement (moderate certainty).

1 finding from 1 review

Comparison 2: 2 days oral amoxicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Neonatal mortality · neonates with possible serious bacterial infection

Comparison 2: 2 days oral amoxicillin + injectable gentamicin… showed no clear difference in neonatal mortality compared with 7 days injectable benzylpenicillin + injectable gentamicin (moderate certainty).

1 finding from 1 review

Comparison 2: 2 days injectable benzylpenicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Neonatal mortality · neonates with possible serious bacterial infection

Comparison 2: 2 days injectable benzylpenicillin + injectable… showed no clear difference in neonatal mortality compared with 7 days injectable benzylpenicillin + injectable gentamicin (low certainty).

1 finding from 1 review

Comparison 1: community‐based antibiotic delivery vs usual care

Late neonatal mortality · neonates with sepsis

Comparison 1: community‐based antibiotic delivery probably leads to lower late neonatal mortality compared with standard care (moderate certainty).

1 finding from 1 review

Comparison 1: community‐based antibiotic delivery vs usual care

Early neonatal mortality · neonates with sepsis

Comparison 1: community‐based antibiotic delivery probably leads to lower early neonatal mortality compared with standard care (moderate certainty).

1 finding from 1 review

Comparison 1: community‐based antibiotic delivery vs usual care

Sepsis‐specific mortality · neonates with sepsis

Comparison 1: community‐based antibiotic delivery showed no clear difference in sepsis‐specific mortality compared with standard care (low certainty).

1 finding from 1 review

Comparison 2: 2 days oral amoxicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Late neonatal mortality · neonates with possible serious bacterial infection

The review found no eligible studies for this question.

1 finding from 1 review

Comparison 2: 2 days injectable benzylpenicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Late neonatal mortality · neonates with possible serious bacterial infection

The review found no eligible studies for this question.

1 finding from 1 review

Comparison 2: 2 days oral amoxicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Early neonatal mortality · neonates with possible serious bacterial infection

The review found no eligible studies for this question.

1 finding from 1 review

Comparison 2: 2 days injectable benzylpenicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Early neonatal mortality · neonates with possible serious bacterial infection

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Perinatal/neonatal death or severe neonatal morbidity ‐ Low national perinatal mortality rate · women with term breech delivery

The intervention probably leads to lower perinatal/neonatal death or severe neonatal morbidity ‐ Low national… (moderate certainty).

1 finding from 1 review

Comparison 2: 2 days oral amoxicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Sepsis‐specific neonatal mortality · neonates with possible serious bacterial infection

The review found no eligible studies for this question.

1 finding from 1 review

Comparison 2: 2 days injectable benzylpenicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Sepsis‐specific neonatal mortality · neonates with possible serious bacterial infection

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings table ‐ Silicone earplugs vs no earplugs

All‐cause mortality during hospital stay · preterm or very low birth weight infants

It is very uncertain whether summary of findings table ‐ Silicone earplugs changes all‐cause mortality during hospital stay compared with no earplugs (very low certainty).

1 finding from 1 review