Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

10 questions · 10 findings · 4 reviews · Emergency and Critical Care

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 7 · 70%Moderate 3 · 30%High 0 · 0%

Thromboelastography (TEG) or thromboelastometry (ROTEM) in combination with SLT or other devices vs clinical judgement or usual care

All‐cause mortality · adults or children with bleeding

Thromboelastography (TEG) or thromboelastometry (ROTEM) in… may leads to lower mortality compared with clinical judgement or usual care (low certainty).

1 finding from 1 review

Thromboelastography (TEG) or thromboelastometry (ROTEM) vs clinical judgement or usual care

All‐cause mortality · adults or children with bleeding

Thromboelastography (TEG) or thromboelastometry (ROTEM) showed no clear difference in mortality compared with clinical judgement or usual care (low certainty).

1 finding from 1 review

Protocol‐directed sedation management vs usual care

ICU mortality · mechanically ventilated ICU adults and children requiring sedation management

Protocol‐directed sedation management showed no clear difference in ICU mortality compared with usual care (low certainty).

1 finding from 1 review

Protocol‐directed sedation management vs usual care

Hospital mortality · mechanically ventilated ICU adults and children requiring sedation management

Protocol‐directed sedation management showed no clear difference in hospital mortality compared with usual care (low certainty).

1 finding from 1 review

Daily sedation interruption vs usual care or protocolized sedation strategies that do not include daily sedation interruption

ICU mortality · Critically ill adults receiving mechanical ventilation in ICU

Daily sedation interruption showed no clear difference in ICU mortality compared with usual care or protocolized sedation strategies that do not include… (moderate certainty).

1 finding from 1 review

Thromboelastography (TEG) or thromboelastometry (ROTEM) vs standard laboratory test (SLT)‐guided transfusion

All‐cause mortality · adults or children with bleeding

Thromboelastography (TEG) or thromboelastometry (ROTEM) may leads to lower mortality compared with standard laboratory test (SLT)‐guided transfusion (low certainty).

1 finding from 1 review

Thromboelastography (TEG) or thromboelastometry (ROTEM) vs any comparison

Mortality within the longest · adults or children with bleeding

Thromboelastography (TEG) or thromboelastometry (ROTEM) may leads to lower mortality longest compared with any comparison (low certainty).

1 finding from 1 review