Findings

What do systematic reviews say?

7 questions · 7 findings · 4 reviews · Hepato-Biliary

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 7 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Ursodeoxycholic acid vs placebo or no intervention

All‐cause mortality · patients with primary biliary cirrhosis.

It is very uncertain whether ursodeoxycholic acid changes all‐cause mortality compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Ursodeoxycholic acid for primary biliary cirrhosis 2012 · Cochrane Headline outcomes only
RR 0.97 [0.67, 1.42]
14 studies · 1391 participants
Very low

Ursodeoxycholic acid vs placebo or no intervention

All‐cause mortality or liver transplantation · patients with primary biliary cirrhosis.

It is very uncertain whether ursodeoxycholic acid changes all‐cause mortality or liver transplantation compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Ursodeoxycholic acid for primary biliary cirrhosis 2012 · Cochrane Headline outcomes only
RR 0.96 [0.74, 1.25]
15 studies · 1419 participants
Very low

Ursodeoxycholic acid vs placebo

All‐cause mortality · people with primary sclerosing cholangitis

It is very uncertain whether ursodeoxycholic acid changes mortality compared with placebo (very low certainty).

1 finding from 1 review

Pharmacological interventions for primary sclerosing cholangitis 2017 · Cochrane Headline outcomes only
OR 1.51 [0.63, 3.63]
2 studies · 348 participants
Very low

Ursodeoxycholic acid vs no intervention

Mortality at maximal · people with primary biliary cholangitis

It is very uncertain whether ursodeoxycholic acid (UDCA) changes mortality at maximal compared with no intervention (very low certainty).

1 finding from 1 review

Pharmacological interventions for primary biliary cholangitis 2017 · Cochrane Headline outcomes only
OR 0.99 [0.6, 1.64]
6 studies · 734 participants
Very low

Colchicine plus ursodeoxycholic acid (UDCA) vs UDCA

Mortality at maximal · people with primary biliary cholangitis

It is very uncertain whether colchicine plus ursodeoxycholic acid (UDCA) changes mortality at maximal compared with UDCA (very low certainty).

1 finding from 1 review

Pharmacological interventions for primary biliary cholangitis 2017 · Cochrane Headline outcomes only
OR 1.84 [0.38, 8.91]
2 studies · 158 participants
Very low

Methotrexate plus ursodeoxycholic acid (UDCA) vs UDCA

Mortality at maximal · people with primary biliary cholangitis

It is very uncertain whether methotrexate plus ursodeoxycholic acid (UDCA) changes mortality at maximal compared with UDCA (very low certainty).

1 finding from 1 review

Pharmacological interventions for primary biliary cholangitis 2017 · Cochrane Headline outcomes only
OR 1.17 [0.55, 2.51]
2 studies · 290 participants
Very low

Bezafibrate vs ursodeoxycholic acid

All‐cause mortality · patients with primary biliary cirrhosis.

It is very uncertain whether bezafibrate changes all‐cause mortality compared with ursodeoxycholic acid (very low certainty).

1 finding from 1 review

Bezafibrate for primary biliary cirrhosis 2012 · Cochrane Headline outcomes only
RD 0
2 studies · 69 participants
Very low