Findings

What do systematic reviews say?

5 questions · 5 findings · 3 reviews · Dementia and Cognitive Improvement

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 40%Low 1 · 20%Moderate 2 · 40%High 0 · 0%

Intensive glycaemic control vs conventional glucose control

All‐cause mortality · patients with type 2 diabetes mellitus

Intensive glycaemic control showed no clear difference in mortality compared with standard glycaemic control (moderate certainty).

1 finding from 1 review · compare the 2 reviews

Effect of the treatment of Type 2 diabetes mellitus on the development of cognitive impairment and dementia 2017 · Cochrane Headline outcomes only
RR 1 [0.79, 1.26]
3 studies · 15888 participants
Moderate

Benzodiazepines (lorazepam) vs chlorpromazine

Mortality from all causes · adult AIDS patients with delirium

It is very uncertain whether benzodiazepines (lorazepam) changes mortality from all causes compared with antipsychotics (chlorpromazine) (very low certainty).

1 finding from 1 review

Benzodiazepines for treatment of patients with delirium excluding those who are cared for in an intensive care unit 2020 · Cochrane Headline outcomes only
RR 0.87 [0.23, 3.26]
1 study · 19 participants
Very low

Benzodiazepines (lorazepam) vs haloperidol

Mortality from all causes · adult AIDS patients with delirium

It is very uncertain whether benzodiazepines (lorazepam) changes mortality from all causes compared with antipsychotics (haloperidol) (very low certainty).

1 finding from 1 review

Benzodiazepines for treatment of patients with delirium excluding those who are cared for in an intensive care unit 2020 · Cochrane Headline outcomes only
RR 1.83 [0.34, 9.92]
1 study · 17 participants
Very low

Benzodiazepines (lorazepam) vs placebo

Mortality from all causes · end‐of‐life patients with advanced cancer and an episode of agitated delirium

Benzodiazepines (lorazepam) showed no clear difference in mortality from all causes compared with placebo (low certainty).

1 finding from 1 review

Benzodiazepines for treatment of patients with delirium excluding those who are cared for in an intensive care unit 2020 · Cochrane Headline outcomes only
RR 0.33 [0.04, 3.02]
1 study · 58 participants
Low

Intervention not reported

Mortality (at 3 to 4 months' · adults with cognitive impairment/dementia and cognitively intact populations

The intervention showed no clear difference in mortality (at 3 to 4 months' (moderate certainty).

1 finding from 1 review

Antihypertensive withdrawal for the prevention of cognitive decline 2016 · Cochrane Headline outcomes only
RR 0.88 [0.72, 1.08]
2 studies · 2485 participants
Moderate