Cochrane · systematic review · CD011971
Antihypertensive withdrawal for the prevention of cognitive decline
Jongstra, S, Harrison, JK, Quinn, TJ, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
Dementia and Cognitive ImprovementAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
5
No studies
2
Included studies
NR
No studies 2 · 28.6%Ungraded 0 · 0%Very low 1 · 14.3%Low 3 · 42.9%Moderate 1 · 14.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Antihypertensive withdrawal for the prevention of cognitive decline
Population: adults with cognitive impairment/dementia and cognitively intact populations
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Incident dementia ‐ not measured | no estimate extracted | NR | No studies |
Cognition (at 90 days): t‐MMSE score1 | no estimate extracted | 1 study · 17842 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Composite cognitive function6 (change over 16 weeks) | no estimate extracted | 1 study · 3517 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Mortality (at 3 to 4 months' | RR 0.88 [0.72, 1.08] | 2 studies · 2485 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |
Cardiovascular events (at 3 to 4 months' | RR 1.29 [0.96, 1.72] | 2 studies · 2485 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Falls ‐ not measured | no estimate extracted | NR | No studies |
Hospitalisations (at 4 months' | RR 0.85 [0.36, 2.06] | 1 study · 388 participants | Low Downgraded: risk of bias, imprecision, indirectness |