Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

22 questions · 22 findings · 12 reviews · Headline outcomes only

No studies found 2 · 9.1%GRADE not reported 0 · 0%Very low 10 · 45.5%Low 8 · 36.4%Moderate 2 · 9.1%High 0 · 0%

Case management for integrated care vs usual care of older people living with frailty

All‐cause mortality · people aged 65 years and older living with frailty

Case management for integrated care showed no clear difference in mortality compared with usual care of older people living with frailty (low certainty).

1 finding from 1 review

Smooth pins vs fixed angle plates

Mortality: at 12 months · older adults (> 60 years of age) with intracapsular hip fractures; most fractures in the included studies were displaced

It is very uncertain whether smooth pins changes mortality: at 12 months compared with fixed angle plates (very low certainty).

1 finding from 1 review

Smooth pins vs fixed angle plates

Mortality: early(within 4 months) · older adults (> 60 years of age) with intracapsular hip fractures; most fractures in the included studies were displaced

It is very uncertain whether smooth pins changes mortality: early(within 4 months) compared with fixed angle plates (very low certainty).

1 finding from 1 review

Screws vs fixed angle plates

Mortality: early (within 4 months) · older adults (> 60 years of age) with intracapsular hip fractures; most fractures in the included studies were displaced

It is very uncertain whether screws changes mortality: early (within 4 months) compared with fixed angle plates (very low certainty).

1 finding from 1 review

Screws vs smooth pins

Mortality: early (within 4 months) · older adults (> 60 years of age) with intracapsular hip fractures; most fractures in the included studies were displaced

It is very uncertain whether screws changes mortality: early (within 4 months) compared with smooth pins (very low certainty).

1 finding from 1 review

Screws or pins vs fixed angle plates

Mortality: early (within 4 months) · older adults (> 60 years of age) with intracapsular hip fractures; most fractures in the included studies were displaced

It is very uncertain whether screws or pins changes mortality: early (within 4 months) compared with fixed angle plates (very low certainty).

1 finding from 1 review

Screws vs fixed angle plates

Mortality at 12 months (Data prioritised at 12 months, but in its absence we included data after 4 months and up to 24 months.) · older adults (> 60 years of age) with intracapsular hip fractures; most fractures in the included studies were displaced

Screws showed no clear difference in mortality at 12 months (Data prioritised at 12 months, but in its… compared with fixed angle plates (low certainty).

1 finding from 1 review

Screws vs smooth pins

Mortality at 12 months (Data prioritised at 12 months, but in its absence we included data after 4 months and up to 24 months.) · older adults (> 60 years of age) with intracapsular hip fractures; most fractures in the included studies were displaced

Screws showed no clear difference in mortality at 12 months (Data prioritised at 12 months, but in its… compared with smooth pins (low certainty).

1 finding from 1 review

Screws or pins vs fixed angle plates

Mortality at 12 months (Data prioritised at 12 months, but in its absence we included data after 4 months and up to 24 months.) · older adults (> 60 years of age) with intracapsular hip fractures; most fractures in the included studies were displaced

Screws or pins showed no clear difference in mortality at 12 months (Data prioritised at 12 months, but in its… compared with fixed angle plates (low certainty).

1 finding from 1 review

Antihypertensive drug therapy vs placebo or no treatment

All‐cause mortality · adults (18 years of age or older) with hypertension‐induced left ventricular hypertrophy

It is very uncertain whether antihypertensive therapy changes all‐cause mortality compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Summary of findings: Any alternative model of care vs usual care

Has died · Nursing home residents (mean age 78.3 to 86.0 years; more than 66% women; 62.1% to 87.3% with dental prostheses)

Summary of findings: Any alternative model of care showed no clear difference in mortality: proportion of residents who died at longest compared with usual care (moderate certainty).

1 finding from 1 review

Intervention not reported

Reduction in mortality · 23 patients aged two years or older with recurrent respiratory papillomatosis

The review found no eligible studies for this question.

1 finding from 1 review

HALOPERIDOL vs placebo

In‐hospital mortality within 28 days. · critically ill patients 18 years or older demanding mechanical ventilation within the first 72 hours (Page 2013) or anticipated needing…

Haloperidol showed no clear difference in in‐hospital mortality within 28 days. compared with placebo (moderate certainty).

1 finding from 1 review

Omega‐3 fatty acids and antioxidants vs standard diet or placebo

Mortality within the longest · adults (aged 18 years or older), mechanically ventilated participants with ARDS as defined by the Berlin definition of ARDS or, for older…

Omega‐3 fatty acids and antioxidants showed no clear difference in all‐cause mortality (longest period reported) compared with placebo or standard nutrition (low certainty).

1 finding from 1 review

Nitroglycerin vs no treatment

All‐cause mortality in 30 days post operation · patients (15 years of age and older) undergoing non‐cardiac surgery under any type of anaesthesia

It is very uncertain whether nitroglycerin changes all‐cause mortality in 30 days post operation compared with no treatment (very low certainty).

1 finding from 1 review