Findings

What do systematic reviews say?

12 questions · 12 findings · 3 reviews · Hepato-Biliary

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No studies found 2 · 16.7%GRADE not reported 0 · 0%Very low 10 · 83.3%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Early vs delayed laparoscopic cholecystectomy

All‐cause mortality · people with biliary colic

It is very uncertain whether early changes mortality compared with delayed laparoscopic cholecystectomy (very low certainty).

1 finding from 1 review

Early versus delayed laparoscopic cholecystectomy for uncomplicated biliary colic 2013 · Cochrane Headline outcomes only
RR 0.38 [0.02, 9.03]
1 study · 75 participants
Very low

Transarterial embolisation plus radiofrequency ablation vs radiofrequency ablation

Mortality at maximal · people with early‐ or very early‐stage hepatocellular carcinoma ineligible for surgery

It is very uncertain whether transarterial embolisation plus radiofrequency ablation changes mortality at maximal compared with radiofrequency ablation (very low certainty).

1 finding from 1 review

Management of people with early‐ or very early‐stage hepatocellular carcinoma 2017 · Cochrane Headline outcomes only
HR 1.12 [0.48, 2.58]
1 study · 44 participants
Very low

Transarterial embolisation plus percutaneous alcohol injection vs percutaneous alcohol injection

Mortality at maximal · people with early‐ or very early‐stage hepatocellular carcinoma ineligible for surgery

It is very uncertain whether transarterial embolisation plus percutaneous alcohol injection changes mortality at maximal compared with percutaneous alcohol injection (very low certainty).

1 finding from 1 review

Management of people with early‐ or very early‐stage hepatocellular carcinoma 2017 · Cochrane Headline outcomes only
HR 0.81 [0.65, 1.01]
2 studies · 202 participants
Very low

Transarterial embolisation plus radiofrequency ablation vs radiofrequency ablation

Cancer‐related mortality at maximal · people with early‐ or very early‐stage hepatocellular carcinoma ineligible for surgery

The review found no eligible studies for this question.

1 finding from 1 review

Management of people with early‐ or very early‐stage hepatocellular carcinoma 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Transarterial embolisation plus percutaneous alcohol injection vs percutaneous alcohol injection

Cancer‐related mortality at maximal · people with early‐ or very early‐stage hepatocellular carcinoma ineligible for surgery

It is very uncertain whether transarterial embolisation plus percutaneous alcohol injection changes cancer‐related mortality at maximal compared with percutaneous alcohol injection (very low certainty).

1 finding from 1 review

Management of people with early‐ or very early‐stage hepatocellular carcinoma 2017 · Cochrane Headline outcomes only
OR 0.07 [0, 1.41]
1 study · 52 participants
Very low

Colchicine vs no intervention

Early mortality (mortality up to 90 days) · participants with alcoholic hepatitis (all severity)

It is very uncertain whether colchicine changes early mortality (mortality up to 90 days) compared with no intervention (very low certainty).

1 finding from 1 review

Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
OR 3.18 [0.13, 81.01]
1 study · 69 participants
Very low

Insulin plus glucagon vs no intervention

Early mortality (mortality up to 90 days) · participants with alcoholic hepatitis (all severity)

It is very uncertain whether insulin plus glucagon changes early mortality (mortality up to 90 days) compared with no intervention (very low certainty).

1 finding from 1 review

Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
OR 2.57 [0.92, 7.15]
1 study · 72 participants
Very low

Glucocorticosteroids vs no intervention

Early mortality (mortality up to 90 days) · participants with alcoholic hepatitis (all severity)

It is very uncertain whether glucocorticosteroids changes early mortality (mortality up to 90 days) compared with no intervention (very low certainty).

1 finding from 1 review

Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
OR 1 [0.71, 1.39]
4 studies · 672 participants
Very low

Propylthiouracil vs no intervention

Early mortality (mortality up to 90 days) · participants with alcoholic hepatitis (all severity)

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Glucocorticosteroids vs no intervention

Early mortality (mortality up to 90 days) · participants with severe alcoholic hepatitis

It is very uncertain whether glucocorticosteroids changes early mortality (mortality up to 90 days) compared with no intervention (very low certainty).

1 finding from 1 review

Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
OR 1.01 [0.71, 1.43]
2 studies · 607 participants
Very low

Pentoxifylline vs no intervention

Early mortality (mortality up to 90 days) · participants with severe alcoholic hepatitis

It is very uncertain whether pentoxifylline changes early mortality (mortality up to 90 days) compared with no intervention (very low certainty).

1 finding from 1 review

Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
OR 1.18 [0.81, 1.74]
1 study · 545 participants
Very low

Pentoxifylline vs no intervention

Early mortality (mortality up to 90 days) · participants with alcoholic hepatitis (all severity)

It is very uncertain whether pentoxifylline changes early mortality (mortality up to 90 days) compared with no intervention (very low certainty).

1 finding from 1 review

Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
OR 1.18 [0.81, 1.74]
1 study · 545 participants
Very low