Findings

What do systematic reviews say?

4 questions · 4 findings · 2 reviews · Dementia and Cognitive Improvement

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 50%Low 0 · 0%Moderate 2 · 50%High 0 · 0%

Antipsychotics vs nonantipsychotics or placebo

All‐cause mortality · delirious patients

Antipsychotics showed no clear difference in mortality compared with nonantipsychotics or placebo (moderate certainty).

1 finding from 1 review

Antipsychotics for treatment of delirium in hospitalised non‐ICU patients 2018 · Cochrane Headline outcomes only
RR 1.29 [0.73, 2.27]
3 studies · 319 participants
Moderate

Typical vs atypical antipsychotics

All‐cause mortality · delirious patients

Typical showed no clear difference in mortality compared with atypical antipsychotics (moderate certainty).

1 finding from 1 review

Antipsychotics for treatment of delirium in hospitalised non‐ICU patients 2018 · Cochrane Headline outcomes only
RR 1.71 [0.82, 3.53]
4 studies · 342 participants
Moderate

Benzodiazepines (lorazepam) vs chlorpromazine

Mortality from all causes · adult AIDS patients with delirium

It is very uncertain whether benzodiazepines (lorazepam) changes mortality from all causes compared with antipsychotics (chlorpromazine) (very low certainty).

1 finding from 1 review

Benzodiazepines for treatment of patients with delirium excluding those who are cared for in an intensive care unit 2020 · Cochrane Headline outcomes only
RR 0.87 [0.23, 3.26]
1 study · 19 participants
Very low

Benzodiazepines (lorazepam) vs haloperidol

Mortality from all causes · adult AIDS patients with delirium

It is very uncertain whether benzodiazepines (lorazepam) changes mortality from all causes compared with antipsychotics (haloperidol) (very low certainty).

1 finding from 1 review

Benzodiazepines for treatment of patients with delirium excluding those who are cared for in an intensive care unit 2020 · Cochrane Headline outcomes only
RR 1.83 [0.34, 9.92]
1 study · 17 participants
Very low